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Tbio
RBX1
E3 ubiquitin-protein ligase RBX1

Protein Summary
Description
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216225
  • ENSP00000216225
  • ENSG00000100387

Symbol
  • RNF75
  • ROC1
  • ROC1
  • RNF75
  • BA554C12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
transcription factor perturbation
0.91
molecular function
0.79
biological process
0.73
transcription factor binding site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.8   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.8   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
83.3
neuroticism measurement
2
2
1
6.4
76.9
worry measurement
2
2
2
5.6
76.1
basophil count
2
2
2
70.9
cognitive function measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
83.3
neuroticism measurement
1
6.4
76.9
worry measurement
2
5.6
76.1
basophil count
2
70.9
cognitive function measurement
1
52
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring-box 1
VGNC:9926
458860
Mouse
MGI:1891829
56438
Rat
RGD:1308453
300084
Horse
ring-box 1
VGNC:22259
100055581
Cow
ring-box 1
518880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring-box 1
Mouse
Rat
Horse
ring-box 1
Cow
ring-box 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62877-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (104)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 82
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Axon guidance
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Axon guidance
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (48)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (697)
1 – 10 of 697
CGGBP1
Tbio
Novelty: 0.10880271
p_int: 0.854601056
p_ni: 0.000234339
p_wrong: 0.145164605
Data Source: BioPlex
CUL5
Tbio
Novelty: 0.00792494
Score: 0.999
Data Source: Reactome,STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.999
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.999
Data Source: Reactome,STRINGDB
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
Score: 0.999
Data Source: Reactome,STRINGDB
CAND1
Tbio
Novelty: 0.0196525
Score: 0.999
Data Source: Reactome,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.999
Data Source: Reactome,STRINGDB
UBE2M
Tbio
Novelty: 0.02353106
Score: 0.999
Data Source: Reactome,STRINGDB
CUL4B
Tbio
Novelty: 0.0133075
Score: 0.999
Data Source: Reactome,STRINGDB
CUL4A
Tbio
Novelty: 0.00917788
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  123.80

PubMed score by year
PubTator Score  119.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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