Tbio POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62875
• P52436
• Q6FHX3
• RNA polymerases I, II, and III subunit ABC5

Gene Name

• POLR2L

Ensembl ID

• ENST00000322028
• ENSP00000324124
• ENSG00000177700
• ENST00000534030
• ENSP00000432807

Symbol

• RBP10
• RPB10
• RPABC5
• RPB7.6
• hRPB7.6
• RPB10beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
biological process	0.88
molecular function	0.73
histone modification site profile	0.64
cellular component	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc5

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc5

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.98   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.98   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0