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Tbio
GNB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378609
  • ENSP00000367872
  • ENSG00000078369
  • ENST00000610897
  • ENSP00000481878

Symbol
  • MRD42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
transcription factor perturbation
0.99
co-expressed gene
0.97
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.01   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (139)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 64
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (1065)
1 – 10 of 1065
GNG2
Tbio
Novelty: 0.08273543
p_int: 0.999801696
p_ni: 0.000198304
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNGT1
Tbio
Novelty: 0.03653174
p_int: 0.999616509
p_ni: 0.000383491
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNG3
Tbio
Novelty: 0.16248863
p_int: 0.979394296
p_ni: 0.020605704
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAI3
Tbio
Novelty: 0.03936457
p_int: 0.914603296
p_ni: 0.085396704
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
p_int: 0.84882286
p_ni: 0.15117714
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00259764
p_int: 0.830664022
p_ni: 0.169335978
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
GNG4
Tdark
Novelty: 0.2302777
p_int: 0.823735589
p_ni: 0.176264411
Score: 0.999
Data Source: BioPlex,STRINGDB
GNGT2
Tbio
Novelty: 0.05824157
Score: 0.999
Data Source: STRINGDB
GNG10
Tdark
Novelty: 0.5797417
Score: 0.999
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  23.01

PubMed score by year
PubTator Score  13.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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