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Tbio
RPS28
40S ribosomal protein S28

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000600659
  • ENSP00000472469
  • ENSG00000233927

Symbol
  • S28
  • eS28
  • DBA15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.96
histone modification site profile
0.88
transcription factor perturbation
0.88
biological process
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (496)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.973188802
p_ni:  0.026811198
Score:  0.239
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.827744881
p_ni:  0.172255119
Score:  0.222
Data Source:  BioPlex,STRINGDB
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.827148696
p_ni:  0.172851304
Data Source:  BioPlex
HMGN4
Tdark
Novelty:  0.01498794
p_int:  0.774527595
p_ni:  0.225472405
Data Source:  BioPlex
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.774513157
p_ni:  0.225486843
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.999
Data Source:  STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.999
Data Source:  STRINGDB
RPL34
Tbio
Novelty:  0.02236592
Score:  0.999
Data Source:  STRINGDB
RPL32
Tbio
Novelty:  0.00279161
Score:  0.999
Data Source:  STRINGDB
RPS17
Tbio
Novelty:  0.00942675
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
8
20
4
99.5
triglyceride measurement
9
3
12
98
apolipoprotein A 1 measurement
2
3
4
97.1
red blood cell distribution width
2
2
3
90.7
serum metabolite measurement
1
3
6
86.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
20
4
99.5
triglyceride measurement
12
98
apolipoprotein A 1 measurement
4
97.1
red blood cell distribution width
3
90.7
serum metabolite measurement
6
86.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S28
VGNC:12082
743298
Macaque
ribosomal protein S28
707133
Macaque
40S ribosomal protein S28 pseudogene
710583
Mouse
MGI:1859516
54127
Rat
RGD:621046
691531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S28
Macaque
ribosomal protein S28
Macaque
40S ribosomal protein S28 pseudogene
Mouse
Rat
Publication Statistics
PubMed Score 26.51
PubMed score by year
PubTator Score 8.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title