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Tbio
RPS25
40S ribosomal protein S25

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000527673
  • ENSP00000435096
  • ENSG00000118181
  • ENST00000628770
  • ENSP00000486392
  • ENSG00000280831

Symbol
  • S25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.97
virus perturbation
0.97
histone modification site profile
0.82


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S25
VGNC:11668
744218
Macaque
40S ribosomal protein S25
695218
Mouse
MGI:1922867
75617
Rat
RGD:621043
122799
Dog
ribosomal protein S25
479412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S25
Macaque
40S ribosomal protein S25
Mouse
Rat
Dog
ribosomal protein S25
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62851-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (453)
1 – 10 of 453
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.974885094
p_ni: 0.025114906
Score: 0.25
Data Source: BioPlex,STRINGDB
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.774875766
p_ni: 0.225124234
Data Source: BioPlex
RPS15
Tbio
Novelty: 0.00635155
Score: 0.999
Data Source: STRINGDB
RPL4
Tbio
Novelty: 0.00475169
Score: 0.999
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.999
Data Source: STRINGDB
RPS3A
Tbio
Novelty: 0.01009445
Score: 0.999
Data Source: STRINGDB
RPL13
Tbio
Novelty: 0.0159486
Score: 0.999
Data Source: STRINGDB
EEF2
Tchem
Novelty: 0.00064095
Score: 0.999
Data Source: STRINGDB
RPS8
Tbio
Novelty: 0.00976281
Score: 0.999
Data Source: STRINGDB
RPL36A
Tbio
Novelty: 0.06115838
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.13

PubMed score by year
PubTator Score  27.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer