You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPS24
40S ribosomal protein S24

Protein Summary
Description
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372360
  • ENSP00000361435
  • ENSG00000138326
  • ENST00000440692
  • ENSP00000414321
  • ENST00000464716
  • ENSP00000494231
  • ENST00000613865
  • ENSP00000478869
  • ENST00000647545
  • ENSP00000495212

Symbol
  • S24
  • DBA3
  • eS24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor binding site profile
0.85
biological process
0.79
co-expressed gene
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (454)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.968932658
p_ni:  0.03106734
p_wrong:  3e-9
Score:  0.577
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.866874598
p_ni:  0.133125402
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.862382475
p_ni:  0.137617525
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.860824106
p_ni:  0.139175894
Score:  0.999
Data Source:  BioPlex,STRINGDB
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.810510941
p_ni:  0.189489059
Data Source:  BioPlex
RPL3
Tbio
Novelty:  0.00566964
Score:  0.999
Data Source:  STRINGDB
RPL27A
Tbio
Novelty:  0.03424762
Score:  0.999
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.999
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
38.8
appendicular lean mass
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
38.8
appendicular lean mass
1
1.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
ribosomal protein S24
100073005
Cow
ribosomal protein S24
530464
Platypus
ribosomal protein S24
100093321
Chicken
ribosomal protein S24
CGNC:3616
423726
Anole lizard
ribosomal protein S24 [Source:HGNC Symbol;Acc:HGNC:10411]
Species
Name
OMA
EggNOG
Inparanoid
Horse
ribosomal protein S24
Cow
ribosomal protein S24
Platypus
ribosomal protein S24
Chicken
ribosomal protein S24
Anole lizard
ribosomal protein S24 [Source:HGNC Symbol;Acc:HGNC:10411]
Publication Statistics
PubMed Score 41.72
PubMed score by year
PubTator Score 42.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title