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Tbio
RPS15
40S ribosomal protein S15

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000592588
  • ENSP00000467466
  • ENSG00000115268

Symbol
  • RIG
  • RIG
  • S15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
microRNA
0.99
disease perturbation
0.97
interacting protein
0.95
biological process
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (520)
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.995430925
p_ni:  0.004569075
Score:  0.999
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.987635114
p_ni:  0.012364886
Score:  0.257
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.981424028
p_ni:  0.018575972
Score:  0.219
Data Source:  BioPlex,STRINGDB
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.978101004
p_ni:  0.021898996
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.968712552
p_ni:  0.031287448
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.966405756
p_ni:  0.033594244
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.965928681
p_ni:  0.034071319
Data Source:  BioPlex
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.965145401
p_ni:  0.034854599
Data Source:  BioPlex
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.963485525
p_ni:  0.036514475
Score:  0.45
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.95581829
p_ni:  0.04418171
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
13.5
hematocrit
1
1
1
13.5
pulse pressure measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
13.5
hematocrit
1
13.5
pulse pressure measurement
1
12.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
40S ribosomal protein S15
455550
Macaque
ribosomal protein S15
707241
Mouse
MGI:98117
20054
Rat
RGD:62026
29285
Dog
ribosomal protein S15
VGNC:45731
476753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
40S ribosomal protein S15
Macaque
ribosomal protein S15
Mouse
Rat
Dog
ribosomal protein S15
Publication Statistics
PubMed Score 147.74
PubMed score by year
PubTator Score 63.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title