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Tbio
RPL23
60S ribosomal protein L23

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394332
  • ENSP00000377865
  • ENSG00000125691
  • ENST00000479035
  • ENSP00000420311

Symbol
  • L23
  • rpL17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
kinase perturbation
0.95
transcription factor binding site profile
0.87
virus perturbation
0.83
interacting protein
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L23
VGNC:9574
454619
Macaque
ribosomal protein L23
694719
Mouse
MGI:1929455
65019
Rat
RGD:62067
29282
Dog
ribosomal protein L23
403683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L23
Macaque
ribosomal protein L23
Mouse
Rat
Dog
ribosomal protein L23
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62829-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (581)
1 – 10 of 581
BCCIP
Tbio
Novelty: 0.02710491
p_int: 0.999771021
p_ni: 0.000228979
Score: 0.768
Data Source: BioPlex,STRINGDB
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.999450563
p_ni: 0.000549437
Data Source: BioPlex
PCDHA10
Tdark
Novelty: 0.73702568
p_int: 0.99768112
p_ni: 0.00231888
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.997602212
p_ni: 0.002397788
Data Source: BioPlex
PCDHGA7
Tdark
Novelty: 1.67766171
p_int: 0.994839172
p_ni: 0.005160828
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.99463449
p_ni: 0.00536551
Data Source: BioPlex
PCDH20
Tbio
Novelty: 0.07862843
p_int: 0.991879965
p_ni: 0.008120035
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.990801037
p_ni: 0.009198963
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.989416154
p_ni: 0.010583846
Data Source: BioPlex
CRP
Tbio
Novelty: 0.00001517
p_int: 0.98868282
p_ni: 0.01131718
Data Source: BioPlex
Publication Statistics
PubMed Score  35.22

PubMed score by year
PubTator Score  14.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer