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Tbio
HIST1H2BC
Histone H2B type 1-C/E/F/G/I

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314332
  • ENSP00000321744
  • ENSG00000180596
  • ENST00000356530
  • ENSP00000348924
  • ENSG00000277224
  • ENST00000377733
  • ENSP00000366962
  • ENSG00000278588
  • ENST00000396984
  • ENSP00000380180
  • ENST00000541790
  • ENSP00000445633
  • ENSG00000273802
  • ENST00000614097
  • ENSP00000483237
  • ENSG00000274290
  • ENST00000634910
  • ENSP00000489317

Symbol
  • H2BFL
  • H2B.1
  • H2B/l
  • H2BFL
  • dJ221C16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
cellular component
0.96
transcription factor perturbation
0.96
small molecule perturbation
0.83
gene perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (335)
Items per page:
1 – 5 of 335
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
10
99.6
red blood cell distribution width
6
7
10
99.6
hemoglobin measurement
5
6
7
99.4
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
Items per page:
1 – 5 of 335
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.6
red blood cell distribution width
10
99.6
hemoglobin measurement
7
99.4
hemoglobin measurement
7
99.4
hematocrit
10
99.3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62807-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (96)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 89
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.991
Data Source:  STRINGDB
HIST1H2AG
Tbio
Novelty:  0.03331195
Score:  0.975
Data Source:  STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
Score:  0.961
Data Source:  STRINGDB
HIST1H2AA
Tbio
Novelty:  0.04021488
Score:  0.953
Data Source:  STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.948
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.948
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.946
Data Source:  STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
Score:  0.936
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.935
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  26.43

PubMed score by year
PubTator Score  2.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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