Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 fa ...more
- ENST00000244537
- ENSP00000244537
- ENSG00000274618
- ENST00000355057
- ENSP00000347168
- ENSG00000197238
- ENST00000358064
- ENSP00000350767
- ENSG00000197837
- ENST00000377727
- ENSP00000366956
- ENSG00000158406
- ENST00000377745
- ENSP00000366974
- ENSG00000278705
- ENST00000377803
- ENSP00000367034
- ENSG00000197061
- ENST00000539745
- ENSP00000443017
- ENST00000578186
- ENSP00000462667
- ENSG00000270882
- ENST00000579512
- ENSP00000462355
- ENSG00000270276
- ENST00000611927
- ENSP00000479794
- ENSG00000273542
- ENST00000612061
- ENSP00000482412
- ENST00000613412
- ENSP00000481343
- ENST00000614247
- ENSP00000479461
- ENSG00000277157
- ENST00000614272
- ENSP00000478519
- ENST00000615164
- ENSP00000484789
- ENSG00000276966
- ENST00000615353
- ENSP00000481486
- ENSG00000276180
- ENST00000617569
- ENSP00000479106
- ENSG00000278637
- ENST00000618193
- ENSP00000478786
- ENST00000618305
- ENSP00000480960
- ENSG00000275126
- ENST00000621520
- ENSP00000481507
- ENST00000634560
- ENSP00000489319
- ENST00000634956
- ENSP00000489567
- ENST00000635491
- ENSP00000489236
- H4/A
- H4FA
- H4/p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.97 | ||
disease | 0.87 | ||
cell line | 0.69 | ||
tissue sample | 0.69 | ||
transcription factor binding site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 603.07 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 1748 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 603.07 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 1748 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0