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Tbio
RPS6
40S ribosomal protein S6

Protein Summary
Description
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380394
  • ENSP00000369757
  • ENSG00000137154

Symbol
  • S6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
1
interacting protein
1
biological process
0.99
microRNA
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.36   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 1161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 691.36   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 1161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (627)
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.937933151
p_ni:  0.062066849
Score:  0.645
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.889934423
p_ni:  0.110065577
Score:  0.559
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.866102447
p_ni:  0.133897553
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.833589097
p_ni:  0.166410903
Score:  0.315
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.758445128
p_ni:  0.241554872
Score:  0.537
Data Source:  BioPlex,STRINGDB
RPF1
Tdark
Novelty:  3.67047505
p_int:  0.751365186
p_ni:  0.248634814
Score:  0.803
Data Source:  BioPlex,STRINGDB
RPL35
Tbio
Novelty:  0.03722634
Score:  0.999
Data Source:  STRINGDB
RPL15
Tbio
Novelty:  0.02466708
Score:  0.999
Data Source:  STRINGDB
RPL10
Tbio
Novelty:  0.01299391
Score:  0.999
Data Source:  STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
Pathways (146)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
1
2
73.5
low density lipoprotein cholesterol measurement
2
2
2
66.6
high density lipoprotein cholesterol measurement
1
1
1
52.7
HMG CoA reductase inhibitor use measurement
1
1
1
31.4
mean corpuscular hemoglobin concentration
1
1
1
17.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
73.5
low density lipoprotein cholesterol measurement
2
66.6
high density lipoprotein cholesterol measurement
1
52.7
HMG CoA reductase inhibitor use measurement
1
31.4
mean corpuscular hemoglobin concentration
1
17.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6
VGNC:4854
469976
Macaque
40S ribosomal protein S6 pseudogene
718556
Mouse
MGI:98159
20104
Dog
ribosomal protein S6
474722
Horse
ribosomal protein S6
VGNC:22556
100052368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6
Macaque
40S ribosomal protein S6 pseudogene
Mouse
Dog
ribosomal protein S6
Horse
ribosomal protein S6
Publication Statistics
PubMed Score 691.36
PubMed score by year
PubTator Score 348.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title