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Tbio
RPL23A
60S ribosomal protein L23a

Protein Summary
Description
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422514
  • ENSP00000389103
  • ENSG00000198242

Symbol
  • L23A
  • MDA20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
disease perturbation
0.95
transcription factor binding site profile
0.92
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
83.2
reticulocyte count
2
2
2
83
reticulocyte measurement
1
1
1
58.4
mean platelet volume
1
1
1
44.2
total cholesterol measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
83.2
reticulocyte count
2
83
reticulocyte measurement
1
58.4
mean platelet volume
1
44.2
total cholesterol measurement
1
35
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L23a
457651
Macaque
60S ribosomal protein L23a
718737
Mouse
MGI:3040672
268449
Rat
RGD:1304897
360572
Rat
RGD:1587481
689899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L23a
Macaque
60S ribosomal protein L23a
Mouse
Rat
Rat
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62750-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (567)
1 – 10 of 567
ANKRD50
Tdark
Novelty:  0.7929169
p_int:  0.999999984
p_ni:  1.5e-8
p_wrong:  1e-9
Data Source:  BioPlex
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.99997363
p_ni:  0.00002637
Data Source:  BioPlex
ZNF622
Tbio
Novelty:  0.26258288
p_int:  0.999970305
p_ni:  0.000029695
p_wrong:  1e-9
Score:  0.553
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999868158
p_ni:  0.00013184
p_wrong:  2e-9
Data Source:  BioPlex
ELAVL4
Tbio
Novelty:  0.00260383
p_int:  0.999587176
p_ni:  0.000406485
p_wrong:  0.000006339
Data Source:  BioPlex
NAP1L1
Tbio
Novelty:  0.03895314
p_int:  0.999514076
p_ni:  0.000485925
Score:  0.238
Data Source:  BioPlex,STRINGDB
RMI1
Tbio
Novelty:  0.01222442
p_int:  0.999318566
p_ni:  0.000012409
p_wrong:  0.000669025
Data Source:  BioPlex
SHCBP1
Tbio
Novelty:  0.09160318
p_int:  0.992940185
p_ni:  0.007056434
p_wrong:  0.000003381
Data Source:  BioPlex
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.988627279
p_ni:  0.011372721
Score:  0.998
Data Source:  BioPlex,STRINGDB
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.98853994
p_ni:  0.01146006
Data Source:  BioPlex
Publication Statistics
PubMed Score  33.50

PubMed score by year
PubTator Score  12.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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