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Tbio
ACTA2
Actin, aortic smooth muscle

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224784
  • ENSP00000224784
  • ENSG00000107796

Symbol
  • ACTSA
  • ACTVS
  • ACTSA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
PubMedID
0.96
transcription factor perturbation
0.94
gene perturbation
0.88
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.41   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 1355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.41   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 1355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (35)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
NOTCH4 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH4
Name
Explore in Pharos
Explore in Source
Muscle contraction
NOTCH4 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH4
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (353)
1 – 10 of 353
ACTA1
Tbio
Novelty: 0.00147233
p_int: 1
Data Source: BioPlex
POTEKP
Tdark
p_int: 0.999999966
p_ni: 3.4e-8
Data Source: BioPlex
MAP3K4
Tbio
Family: Kinase
Novelty: 0.02920916
p_int: 0.999973478
p_ni: 0.000026521
Score: 0.177
Data Source: BioPlex,STRINGDB
LRRC20
Tdark
Novelty: 7
p_int: 0.999942079
p_ni: 0.000057921
Data Source: BioPlex
PHACTR2
Tbio
Family: Enzyme
Novelty: 0.35294118
p_int: 0.999918548
p_ni: 0.000081452
Score: 0.719
Data Source: BioPlex,STRINGDB
PFN3
Tdark
Novelty: 0.13982839
p_int: 0.999895525
p_ni: 0.000104475
Score: 0.186
Data Source: BioPlex,STRINGDB
NPB
Tdark
Novelty: 0.00254878
p_int: 0.999771369
p_ni: 0.000228631
Data Source: BioPlex
TMOD3
Tbio
Novelty: 0.06428995
p_int: 0.999691923
p_ni: 0.000308077
Score: 0.386
Data Source: BioPlex,STRINGDB
THRB
Tclin
Family: NR
Novelty: 0.0014337
p_int: 0.999448748
p_ni: 0.000551252
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00027728
p_int: 0.999330741
p_ni: 0.000669259
Score: 0.563
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  327.41

PubMed score by year
PubTator Score  144.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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