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Tbio
PPP2CB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Protein Summary
Description
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221138
  • ENSP00000221138
  • ENSG00000104695

Symbol
  • PP2CB
  • PP2Abeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.9
virus perturbation
0.9
disease perturbation
0.83
pathway
0.78
interacting protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (405)
TBCCD1
Tbio
Novelty:  0.21991508
p_int:  1
Score:  0.663
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.999999972
p_ni:  2.7e-8
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.999999938
p_ni:  4e-8
p_wrong:  2.2e-8
Score:  0.719
Data Source:  BioPlex,STRINGDB
PPP2R3C
Tbio
Family:  Enzyme
Novelty:  0.02970644
p_int:  0.999999917
p_ni:  8.2e-8
p_wrong:  1e-9
Score:  0.906
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.999999805
p_ni:  1.95e-7
Score:  0.803
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999999783
p_ni:  2.17e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
CEP350
Tbio
Novelty:  0.09063779
p_int:  0.999999693
p_ni:  3.03e-7
p_wrong:  3e-9
Score:  0.586
Data Source:  BioPlex,STRINGDB
PPP2R3B
Tbio
Family:  Enzyme
Novelty:  0.02932064
p_int:  0.999999488
p_ni:  5.12e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999998063
p_ni:  0.000001937
Score:  0.659
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.999997093
p_ni:  0.000002907
Score:  0.99
Data Source:  BioPlex,STRINGDB
Pathways (153)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

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Find Similar Targets
Items per page:
1 – 5 of 122
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 2 catalytic subunit beta
695118
Mouse
MGI:1321161
19053
Rat
RGD:3381
24673
Dog
protein phosphatase 2 catalytic subunit beta
VGNC:44904
482873
Horse
protein phosphatase 2 catalytic subunit beta
100062224
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 2 catalytic subunit beta
Mouse
Rat
Dog
protein phosphatase 2 catalytic subunit beta
Horse
protein phosphatase 2 catalytic subunit beta
Publication Statistics
PubMed Score 17.23
PubMed score by year
PubTator Score 9.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title