You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPP2CB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Protein Summary
Description
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221138
  • ENSP00000221138
  • ENSG00000104695

Symbol
  • PP2CB
  • PP2Abeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.9
virus perturbation
0.9
disease perturbation
0.83
pathway
0.78
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 366   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (153)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 122
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Protein-Protein Interactions (405)
1 – 10 of 405
TBCCD1
Tbio
Novelty: 0.3
p_int: 1
Score: 0.663
Data Source: BioPlex,STRINGDB
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.07465785
p_int: 0.999999972
p_ni: 2.7e-8
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
STRIP2
Tbio
Novelty: 0.15494343
p_int: 0.999999938
p_ni: 4e-8
p_wrong: 2.2e-8
Score: 0.719
Data Source: BioPlex,STRINGDB
PPP2R3C
Tbio
Family: Enzyme
Novelty: 0.06409629
p_int: 0.999999917
p_ni: 8.2e-8
p_wrong: 1e-9
Score: 0.906
Data Source: BioPlex,STRINGDB
PRR14
Tbio
Novelty: 0.16853933
p_int: 0.999999805
p_ni: 1.95e-7
Score: 0.803
Data Source: BioPlex,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.10054323
p_int: 0.999999783
p_ni: 2.17e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
CEP350
Tbio
Novelty: 0.09631923
p_int: 0.999999693
p_ni: 3.03e-7
p_wrong: 3e-9
Score: 0.586
Data Source: BioPlex,STRINGDB
PPP2R3B
Tbio
Family: Enzyme
Novelty: 0.03678679
p_int: 0.999999488
p_ni: 5.12e-7
Score: 0.967
Data Source: BioPlex,STRINGDB
SLMAP
Tbio
Novelty: 0.04279507
p_int: 0.999998063
p_ni: 0.000001937
Score: 0.659
Data Source: BioPlex,STRINGDB
PPP2R5A
Tchem
Family: Enzyme
Novelty: 0.07288957
p_int: 0.999997093
p_ni: 0.000002907
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.75

PubMed score by year
PubTator Score  9.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer