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Tbio
RPS4X
40S ribosomal protein S4, X isoform

Protein Summary
Description
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316084
  • ENSP00000362744
  • ENSG00000198034

Symbol
  • CCG2
  • RPS4
  • SCAR
  • S4
  • CCG2
  • RPS4
  • SCAR
  • SCR10
  • DXS306
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
small molecule perturbation
1
hub protein
0.96
biological process
0.86
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (527)
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.999659643
p_ni:  0.000340355
p_wrong:  2e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.999552893
p_ni:  0.000447107
Score:  0.241
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.981825145
p_ni:  0.018174855
Score:  0.335
Data Source:  BioPlex,STRINGDB
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.980037914
p_ni:  0.019962086
Data Source:  BioPlex
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.938018784
p_ni:  0.061981216
Score:  0.177
Data Source:  BioPlex,STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.787847486
p_ni:  0.212152514
Score:  0.163
Data Source:  BioPlex,STRINGDB
RPS19
Tbio
Novelty:  0.00380084
Score:  0.999
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.999
Data Source:  STRINGDB
RPL14
Tbio
Novelty:  0.01600377
Score:  0.999
Data Source:  STRINGDB
RPL28
Tbio
Novelty:  0.03136035
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
54.3
sodium measurement
1
1
1
42.2
chloride measurement
1
1
1
33
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
54.3
sodium measurement
1
42.2
chloride measurement
1
33
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S4 X-linked
VGNC:14718
465710
Macaque
ribosomal protein S4, X-linked
699397
Mouse
MGI:98158
20102
Rat
Dog
ribosomal protein S4, X-linked
403893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S4 X-linked
Macaque
ribosomal protein S4, X-linked
Mouse
Rat
Dog
ribosomal protein S4, X-linked
Publication Statistics
PubMed Score 72.37
PubMed score by year
PubTator Score 116.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title