Tbio YPEL5 Protein yippee-like 5

Protein Summary

Description

Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity).

Uniprot Accession IDs

• P62699
• D6W568
• Q65Z97
• Q8R174
• Q9D6M1
• Q9UMX7
• Q9Y3C9

Gene Name

• YPEL5

Ensembl ID

• ENST00000261353
• ENSP00000261353
• ENSG00000119801
• ENST00000379519
• ENSP00000368834
• ENST00000379520
• ENSP00000368835
• ENST00000402003
• ENSP00000383974
• ENST00000402708
• ENSP00000385278

Symbol

• CGI-127

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
kinase perturbation	0.96
transcription factor binding site profile	0.9
virus perturbation	0.83
PubMedID	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.62   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.62   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0