ESRRG
Estrogen-related receptor gamma
Protein Classes
Protein Summary
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen r ...more
- ENST00000359162
- ENSP00000352077
- ENSG00000196482
- ENST00000360012
- ENSP00000353108
- ENST00000361395
- ENSP00000354584
- ENST00000361525
- ENSP00000355225
- ENST00000366937
- ENSP00000355904
- ENST00000366938
- ENSP00000355905
- ENST00000366940
- ENSP00000355907
- ENST00000391890
- ENSP00000375761
- ENST00000408911
- ENSP00000386171
- ENST00000463665
- ENSP00000418629
- ENST00000487276
- ENSP00000419155
- ENST00000493603
- ENSP00000419594
- ENST00000493748
- ENSP00000417374
- ENST00000616180
- ENSP00000481528
- ERR3
- ERRG2
- KIAA0832
- NR3B3
- ERR3
- ERRg
- NR3B3
- ERRgamma
- ERR-gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
molecular function | 0.97 | ||
protein domain | 0.97 | ||
microRNA | 0.78 | ||
phenotype | 0.75 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.32 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 463 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.32 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 463 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (11)
1 – 10 of 11
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 4 | 5 | 93.1 | |||||
self reported educational attainment | 2 | 2 | 2 | 90.7 | |||||
cognitive function measurement | 3 | 2 | 3 | 88.1 | |||||
testosterone measurement | 2 | 2 | 2 | 84 | |||||
hematocrit | 2 | 3 | 3 | 79 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 5 | 93.1 | |||||
self reported educational attainment | 2 | 90.7 | |||||
cognitive function measurement | 3 | 88.1 | |||||
testosterone measurement | 2 | 84 | |||||
hematocrit | 3 | 79 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | estrogen related receptor gamma | VGNC:6793 | 457738 | |||||
Macaque | estrogen-related receptor gamma-like | 106992350 | ||||||
Mouse | MGI:1347056 | 26381 | ||||||
Rat | RGD:1303236 | 360896 | ||||||
Dog | estrogen related receptor gamma | VGNC:40481 | 478961 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | estrogen related receptor gamma | |||||
Macaque | estrogen-related receptor gamma-like | |||||
Mouse | ||||||
Rat | ||||||
Dog | estrogen related receptor gamma | |||||
Protein Structure (16 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 16
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Nuclear Receptor transcription pathway | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (13)
Functions (8)
Components (1)
Processes (4)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (52)
1 – 10 of 52
PPARGC1B
Novelty: 0.01004477
Score: 0.933
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.918
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.917
Data Source: STRINGDB
NRIP1
Novelty: 0.00551568
Score: 0.913
Data Source: STRINGDB
PNRC2
Novelty: 0.08731548
Score: 0.87
Data Source: STRINGDB
TLE1
Novelty: 0.00594261
Score: 0.85
Data Source: STRINGDB
PPARGC1A
Novelty: 0.0003625
Score: 0.836
Data Source: STRINGDB
NCOR2
Family: TF
Novelty: 0.00066449
Score: 0.816
Data Source: STRINGDB
ESRRA
Family: NR
Novelty: 0.003235
Score: 0.813
Data Source: STRINGDB
NCOR1
Family: TF
Novelty: 0.0021926
Score: 0.778
Data Source: STRINGDB
Publication Statistics
PubMed Score 222.32
PubMed score by year
PubTator Score 92.96
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait