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Tchem
ESRRG
Estrogen-related receptor gamma

Protein Summary
Description
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359162
  • ENSP00000352077
  • ENSG00000196482
  • ENST00000360012
  • ENSP00000353108
  • ENST00000361395
  • ENSP00000354584
  • ENST00000361525
  • ENSP00000355225
  • ENST00000366937
  • ENSP00000355904
  • ENST00000366938
  • ENSP00000355905
  • ENST00000366940
  • ENSP00000355907
  • ENST00000391890
  • ENSP00000375761
  • ENST00000408911
  • ENSP00000386171
  • ENST00000463665
  • ENSP00000418629
  • ENST00000487276
  • ENSP00000419155
  • ENST00000493603
  • ENSP00000419594
  • ENST00000493748
  • ENSP00000417374
  • ENST00000616180
  • ENSP00000481528

Symbol
  • ERR3
  • ERRG2
  • KIAA0832
  • NR3B3
  • ERR3
  • ERRg
  • NR3B3
  • ERRgamma
  • ERR-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
molecular function
0.97
protein domain
0.97
microRNA
0.78
phenotype
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.39   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.39   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1