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Tchem
ESRRG
Estrogen-related receptor gamma

Protein Summary
Description
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359162
  • ENSP00000352077
  • ENSG00000196482
  • ENST00000360012
  • ENSP00000353108
  • ENST00000361395
  • ENSP00000354584
  • ENST00000361525
  • ENSP00000355225
  • ENST00000366937
  • ENSP00000355904
  • ENST00000366938
  • ENSP00000355905
  • ENST00000366940
  • ENSP00000355907
  • ENST00000391890
  • ENSP00000375761
  • ENST00000408911
  • ENSP00000386171
  • ENST00000463665
  • ENSP00000418629
  • ENST00000487276
  • ENSP00000419155
  • ENST00000493603
  • ENSP00000419594
  • ENST00000493748
  • ENSP00000417374
  • ENST00000616180
  • ENSP00000481528

Symbol
  • ERR3
  • ERRG2
  • KIAA0832
  • NR3B3
  • ERR3
  • ERRg
  • NR3B3
  • ERRgamma
  • ERR-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
molecular function
0.97
protein domain
0.97
microRNA
0.78
phenotype
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.32   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.32   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
4
5
93.1
self reported educational attainment
2
2
2
90.7
cognitive function measurement
3
2
3
88.1
testosterone measurement
2
2
2
84
hematocrit
2
3
3
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
93.1
self reported educational attainment
2
90.7
cognitive function measurement
3
88.1
testosterone measurement
2
84
hematocrit
3
79
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor gamma
VGNC:6793
457738
Macaque
estrogen-related receptor gamma-like
106992350
Mouse
MGI:1347056
26381
Rat
RGD:1303236
360896
Dog
estrogen related receptor gamma
VGNC:40481
478961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor gamma
Macaque
estrogen-related receptor gamma-like
Mouse
Rat
Dog
estrogen related receptor gamma
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62508-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (52)
1 – 10 of 52
PPARGC1B
Tbio
Novelty: 0.01004477
Score: 0.933
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.918
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.917
Data Source: STRINGDB
NRIP1
Tbio
Novelty: 0.00551568
Score: 0.913
Data Source: STRINGDB
PNRC2
Tbio
Novelty: 0.08731548
Score: 0.87
Data Source: STRINGDB
TLE1
Tbio
Novelty: 0.00594261
Score: 0.85
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.836
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.816
Data Source: STRINGDB
ESRRA
Tchem
Family: NR
Novelty: 0.003235
Score: 0.813
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.778
Data Source: STRINGDB
Publication Statistics
PubMed Score  222.32

PubMed score by year
PubTator Score  92.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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