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Tbio
RAB11A
Ras-related protein Rab-11A

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261890
  • ENSP00000261890
  • ENSG00000103769
  • ENST00000569896
  • ENSP00000456420

Symbol
  • RAB11
  • YL8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.97
disease perturbation
0.97
transcription factor perturbation
0.97
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.55   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.55   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
2
3
90
mean corpuscular volume
3
2
3
83.4
red blood cell density measurement
1
1
1
83
mean corpuscular hemoglobin
2
2
2
78.9
body mass index
1
1
1
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
90
mean corpuscular volume
3
83.4
red blood cell density measurement
1
83
mean corpuscular hemoglobin
2
78.9
body mass index
1
76.2
Protein Data Bank (27)
1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Aquaporin-mediated transport
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Aquaporin-mediated transport
Cargo trafficking to the periciliary membrane
Cilium Assembly
Membrane Trafficking
Gene Ontology Terms (58)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (502)
1 – 10 of 502
RAB11FIP2
Tbio
Novelty: 0.06330621
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RAB11FIP5
Tbio
Novelty: 0.0264203
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
RAB11FIP1
Tbio
Novelty: 0.0445306
p_int: 0.999999948
p_ni: 5.2e-8
Score: 0.966
Data Source: BioPlex,STRINGDB
RAB25
Tbio
Family: Enzyme
Novelty: 0.01889483
p_int: 0.999999784
p_wrong: 2.15e-7
Score: 0.919
Data Source: BioPlex,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999968725
p_ni: 0.000031274
p_wrong: 1e-9
Score: 0.931
Data Source: BioPlex,STRINGDB
SH3BP5
Tbio
Novelty: 0.00597871
p_int: 0.999956205
p_ni: 1.49e-7
p_wrong: 0.000043646
Score: 0.446
Data Source: BioPlex,STRINGDB
DNPEP
Tchem
Family: Enzyme
Novelty: 0.02415651
p_int: 0.999890205
p_ni: 0.000109795
Score: 0.203
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999871831
p_ni: 0.000128141
p_wrong: 2.9e-8
Score: 0.944
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.999547747
p_ni: 0.000452253
Score: 0.636
Data Source: BioPlex,STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
p_int: 0.995095929
p_ni: 0.004904068
p_wrong: 3e-9
Score: 0.202
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  662.55

PubMed score by year
PubTator Score  341.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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