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Tbio
POLR2G
DNA-directed RNA polymerase II subunit RPB7

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA. This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301788
  • ENSP00000301788
  • ENSG00000168002

Symbol
  • RPB7
  • RPB7
  • RPB19
  • hRPB19
  • hsRPB7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
biological process
0.93
disease perturbation
0.9
virus perturbation
0.9
cell type or tissue
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (600)
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999999997
p_ni:  3e-9
Score:  0.851
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.99999996
p_ni:  3.9e-8
p_wrong:  1e-9
Score:  0.835
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999999802
p_ni:  1.98e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999990731
p_ni:  0.000009269
Score:  0.994
Data Source:  BioPlex,STRINGDB
RPRD1A
Tbio
Novelty:  0.13521196
p_int:  0.999971083
p_ni:  0.000028915
p_wrong:  2e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.999969909
p_ni:  0.000030091
Score:  0.851
Data Source:  BioPlex,STRINGDB
CTDP1
Tbio
Family:  Enzyme
Novelty:  0.01121863
p_int:  0.999910207
p_ni:  0.000003448
p_wrong:  0.000086344
Score:  0.996
Data Source:  BioPlex,STRINGDB
RPRD2
Tdark
Novelty:  0.45063764
p_int:  0.99964524
p_ni:  0.00035475
p_wrong:  1.1e-8
Score:  0.973
Data Source:  BioPlex,STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
p_int:  0.999549765
p_ni:  0.000444358
p_wrong:  0.000005877
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
38.2
smoking status measurement
1
1
1
26.6
BMI-adjusted waist-hip ratio
1
1
1
15.8
waist-hip ratio
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
38.2
smoking status measurement
1
26.6
BMI-adjusted waist-hip ratio
1
15.8
waist-hip ratio
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II subunit G
718548
Mouse
MGI:1914960
67710
Rat
RGD:621284
117017
Horse
RNA polymerase II subunit G
VGNC:21679
100063883
Cow
RNA polymerase II subunit G
VGNC:33141
526320
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA polymerase II subunit G
Mouse
Rat
Horse
RNA polymerase II subunit G
Cow
RNA polymerase II subunit G
Publication Statistics
PubMed Score 81.16
PubMed score by year
PubTator Score 25.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title