Tbio RPL7A 60S ribosomal protein L7a

Protein Summary

Description

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62424
• P11518
• Q5T8U4

Gene Name

• RPL7A

Ensembl ID

• ENST00000323345
• ENSP00000361076
• ENSG00000148303
• ENST00000630979
• ENSP00000487443
• ENSG00000280858

Symbol

• SURF-3
• SURF3
• L7A
• TRUP
• SURF3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	0.99
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L7a

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L7a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.4   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.4   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0