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Tbio
RPL7A
60S ribosomal protein L7a

Protein Summary
Description
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N te ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323345
  • ENSP00000361076
  • ENSG00000148303
  • ENST00000630979
  • ENSP00000487443
  • ENSG00000280858

Symbol
  • SURF-3
  • SURF3
  • L7A
  • TRUP
  • SURF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
0.99
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (332)
Items per page:
1 – 5 of 332
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
7
10
10
8.8
99.8
alkaline phosphatase measurement
7
10
10
8.8
99.8
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
venous thromboembolism
9
11
2
1.5
99.7
Items per page:
1 – 5 of 332
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
10
8.8
99.8
alkaline phosphatase measurement
10
8.8
99.8
low density lipoprotein cholesterol measurement
36
2.9
99.8
low density lipoprotein cholesterol measurement
36
2.9
99.8
venous thromboembolism
2
1.5
99.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L7a
722215
Rat
RGD:1307586
296596
Dog
ribosomal protein L7a
403678
Cow
ribosomal protein L7a
VGNC:49957
513128
Opossum
ribosomal protein L7a
100018260
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L7a
Rat
Dog
ribosomal protein L7a
Cow
ribosomal protein L7a
Opossum
ribosomal protein L7a
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62424-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (545)
1 – 10 of 545
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999999996
p_ni:  4e-9
Data Source:  BioPlex
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999997945
p_ni:  0.000002055
Data Source:  BioPlex
PCDHGC4
Tdark
Novelty:  0.79832188
p_int:  0.999946396
p_ni:  0.000053604
Data Source:  BioPlex
LAD1
Tbio
Novelty:  0.03059679
p_int:  0.999692986
p_ni:  0.000307014
Data Source:  BioPlex
ZNF16
Tbio
Family:  TF
Novelty:  0.18433365
p_int:  0.999067722
p_ni:  0.000382143
p_wrong:  0.000550135
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.998767892
p_ni:  0.001226512
p_wrong:  0.000005596
Data Source:  BioPlex
ZNF317
Tdark
Family:  TF
Novelty:  1.58030176
p_int:  0.998080974
p_ni:  0.001917865
p_wrong:  0.000001161
Data Source:  BioPlex
DCAF1
Tbio
Novelty:  0.0170232
p_int:  0.997230131
p_ni:  0.002769869
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.996890646
p_ni:  0.003109354
Score:  0.29
Data Source:  BioPlex,STRINGDB
ZNF189
Tdark
Family:  TF
Novelty:  0.28362251
p_int:  0.995686825
p_ni:  0.004221527
p_wrong:  0.000091648
Data Source:  BioPlex
Publication Statistics
PubMed Score  56.06

PubMed score by year
PubTator Score  27.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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