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Tbio
SELENOT
Thioredoxin reductase-like selenoprotein T

Protein Summary
Description
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000471696
  • ENSP00000418910
  • ENSG00000198843

Symbol
  • SELT
  • SELT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein T
VGNC:53379
738216
Macaque
selenoprotein T
710572
Mouse
MGI:1916477
69227
Dog
selenoprotein T
VGNC:52902
477113
Horse
selenoprotein T [Source:HGNC Symbol;Acc:HGNC:18136]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein T
Macaque
selenoprotein T
Mouse
Dog
selenoprotein T
Horse
selenoprotein T [Source:HGNC Symbol;Acc:HGNC:18136]
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Selenium Micronutrient Network
WikiPathways
Eukaryotic Transcription Initiation
WikiPathways
Selenium Metabolism and Selenoproteins
WikiPathways
Cytosolic DNA-sensing pathway
Name
Explore in Pharos
Explore in Source
Selenium Micronutrient Network
Eukaryotic Transcription Initiation
Selenium Metabolism and Selenoproteins
Cytosolic DNA-sensing pathway
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (71)
1 – 10 of 71
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.999970444
p_ni: 0.000029205
p_wrong: 3.51e-7
Data Source: BioPlex
TEX28
Tdark
Novelty: 0.10581423
p_int: 0.999845271
p_ni: 0.000154729
Data Source: BioPlex
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
p_int: 0.99971896
p_ni: 0.000277178
p_wrong: 0.000003862
Data Source: BioPlex
ARSE
Tbio
Family: Enzyme
Novelty: 0.00151862
p_int: 0.998909521
p_ni: 0.000723361
p_wrong: 0.000367118
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.998702876
p_ni: 0.00129711
p_wrong: 1.4e-8
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.998482579
p_ni: 0.00151742
p_wrong: 1e-9
Data Source: BioPlex
SCPEP1
Tbio
Family: Enzyme
Novelty: 0.08603794
p_int: 0.997921491
p_ni: 0.002077059
p_wrong: 0.00000145
Data Source: BioPlex
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.996960052
p_ni: 0.001733174
p_wrong: 0.001306774
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.995445461
p_ni: 0.003547374
p_wrong: 0.001007165
Data Source: BioPlex
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.990726337
p_ni: 0.007568394
p_wrong: 0.00170527
Score: 0.207
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.31

PubMed score by year
PubTator Score  9.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer