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Tbio
ARF6
ADP-ribosylation factor 6

Protein Summary
Description
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity). (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. This gene encodes a member of the human ARF gene fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298316
  • ENSP00000298316
  • ENSG00000165527
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
transcription factor binding site profile
0.95
molecular function
0.94
biological term
0.91
cellular component
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.34   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.34   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
1
2
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
77.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99435
11845
Rat
RGD:621279
79121
Dog
ADP ribosylation factor 6
VGNC:38031
490679
Horse
ADP ribosylation factor 6
VGNC:15446
100065920
Cow
ADP ribosylation factor 6
VGNC:26061
100294979
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ADP ribosylation factor 6
Horse
ADP ribosylation factor 6
Cow
ADP ribosylation factor 6
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62330-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
MET receptor recycling
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
MET receptor recycling
Membrane Trafficking
Rab regulation of trafficking
Signal Transduction
Gene Ontology Terms (49)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (332)
1 – 10 of 332
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.999302841
p_ni:  0.000697159
Score:  0.46
Data Source:  BioPlex,STRINGDB
MUC20
Tbio
Novelty:  0.04645313
p_int:  0.995902525
p_ni:  0.004097454
p_wrong:  2.2e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.995848568
p_ni:  0.004151327
p_wrong:  1.05e-7
Score:  0.557
Data Source:  BioPlex,STRINGDB
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.990357736
p_ni:  0.009642264
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.94656254
p_ni:  0.05343746
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.914190697
p_ni:  0.069765229
p_wrong:  0.016044074
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.910230456
p_ni:  0.089769539
p_wrong:  4e-9
Score:  0.241
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.894149743
p_ni:  0.105842195
p_wrong:  0.000008061
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.882569177
p_ni:  0.117430812
p_wrong:  1.1e-8
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.874254227
p_ni:  0.125745762
p_wrong:  1.1e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  429.34

PubMed score by year
PubTator Score  339

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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