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Tbio
ARF6
ADP-ribosylation factor 6

Protein Summary
Description
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity). (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. This gene encodes a member of the human ARF gene fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298316
  • ENSP00000298316
  • ENSG00000165527
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
transcription factor binding site profile
0.95
molecular function
0.94
biological term
0.91
cellular component
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.58   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.58   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
MET receptor recycling
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
MET receptor recycling
Membrane Trafficking
Rab regulation of trafficking
Signal Transduction
Gene Ontology Terms (49)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (332)
1 – 10 of 332
TGOLN2
Tbio
Novelty: 0.00791111
p_int: 0.999302841
p_ni: 0.000697159
Score: 0.46
Data Source: BioPlex,STRINGDB
MUC20
Tbio
Novelty: 0.07155729
p_int: 0.995902525
p_ni: 0.004097454
p_wrong: 2.2e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
MYADM
Tbio
Novelty: 0.09214874
p_int: 0.995848568
p_ni: 0.004151327
p_wrong: 1.05e-7
Score: 0.557
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.05657813
p_int: 0.990357736
p_ni: 0.009642264
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.00944493
p_int: 0.94656254
p_ni: 0.05343746
Data Source: BioPlex
FGFR2
Tclin
Family: Kinase
Novelty: 0.00077461
p_int: 0.914190697
p_ni: 0.069765229
p_wrong: 0.016044074
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 6
p_int: 0.910230456
p_ni: 0.089769539
p_wrong: 4e-9
Score: 0.241
Data Source: BioPlex,STRINGDB
YAF2
Tbio
Novelty: 0.14775726
p_int: 0.894149743
p_ni: 0.105842195
p_wrong: 0.000008061
Data Source: BioPlex
PDCD1
Tclin
Novelty: 0.00079757
p_int: 0.882569177
p_ni: 0.117430812
p_wrong: 1.1e-8
Data Source: BioPlex
MSMB
Tbio
Novelty: 0.00164465
p_int: 0.874254227
p_ni: 0.125745762
p_wrong: 1.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  374.58

PubMed score by year
PubTator Score  339

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer