Protein Summary
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
- ENST00000380633
- ENSP00000370007
- ENSG00000205542
- ENST00000380635
- ENSP00000370009
- ENST00000380636
- ENSP00000370010
- ENST00000451311
- ENSP00000414376
- TB4X
- THYB4
- TMSB4
- FX
- TB4X
- PTMB4
- TMSB4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 1 | ||
PubMedID | 0.8 | ||
histone modification site profile | 0.72 | ||
transcription factor binding site profile | 0.69 | ||
biological term | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 580.24 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 580.24 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
childhood onset asthma | 1 | 1 | 0 | 1 | 5.2 | ||||
1 | 1 | 0 | 1 | 3.9 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
childhood onset asthma | 0 | 1 | 5.2 | ||||
0 | 1 | 3.9 | |||||
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:99510 | 19241 | ||||||
Horse | thymosin beta 4, X-linked | 100034015 | ||||||
Pig | thymosin beta 4, X-linked | 733606 | ||||||
Anole lizard | thymosin beta 4, X-linked | 100560572 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Horse | thymosin beta 4, X-linked | |||||
Pig | thymosin beta 4, X-linked | |||||
Anole lizard | thymosin beta 4, X-linked | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (4)
KEGG (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Gene Ontology Terms (26)
Functions (3)
Components (7)
Processes (16)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Protein-Protein Interactions (110)
1 – 10 of 110
ACTA1
Novelty: 0.00111813
Score: 0.98
Data Source: STRINGDB
ACTB
Novelty: 0.00006048
Score: 0.971
Data Source: STRINGDB
ACTG1
Novelty: 0.00086444
Score: 0.968
Data Source: STRINGDB
VEGFA
Novelty: 0.0000378
Score: 0.958
Data Source: STRINGDB
PPBP
Novelty: 0.00048307
Score: 0.924
Data Source: STRINGDB
SPARC
Novelty: 0.00063267
Score: 0.923
Data Source: STRINGDB
PF4
Novelty: 0.00038481
Score: 0.923
Data Source: STRINGDB
ACTN1
Novelty: 0.00654004
Score: 0.922
Data Source: STRINGDB
FN1
Novelty: 0.00003647
Score: 0.921
Data Source: STRINGDB
SERPINA1
Novelty: 0.00014098
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score 580.24
PubMed score by year
PubTator Score 250.63
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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