Protein Summary
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
- ENST00000380633
- ENSP00000370007
- ENSG00000205542
- ENST00000380635
- ENSP00000370009
- ENST00000380636
- ENSP00000370010
- ENST00000451311
- ENSP00000414376
- TB4X
- THYB4
- TMSB4
- FX
- TB4X
- PTMB4
- TMSB4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 1 | ||
PubMedID | 0.8 | ||
histone modification site profile | 0.72 | ||
transcription factor binding site profile | 0.69 | ||
biological term | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 596.57 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 596.57 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (110)
Nearest Tclin Targets
Pathways (8)
Reactome (4)
KEGG (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (3)
Components (7)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
childhood onset asthma | 1 | 1 | 0 | 1 | 12.2 | ||||
1 | 1 | 0 | 1 | 9.9 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
childhood onset asthma | 0 | 1 | 12.2 | ||||
0 | 1 | 9.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:99510 | 19241 | ||||||
Horse | thymosin beta 4, X-linked | 100034015 | ||||||
Pig | thymosin beta 4, X-linked | 733606 | ||||||
Anole lizard | thymosin beta 4, X-linked | 100560572 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Horse | thymosin beta 4, X-linked | |||||
Pig | thymosin beta 4, X-linked | |||||
Anole lizard | thymosin beta 4, X-linked | |||||
Publication Statistics
PubMed Score 596.57
PubMed score by year
PubTator Score 250.63
PubTator score by year
Related Publications
Text Mined References (104)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
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