Tbio TMSB4X Thymosin beta-4

Protein Summary

Description

Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62328
• P01253
• P01254
• Q546P5
• Q63576
• Q9UE55
• T beta-4

Gene Name

• TMSB4X

Ensembl ID

• ENST00000380633
• ENSP00000370007
• ENSG00000205542
• ENST00000380635
• ENSP00000370009
• ENST00000380636
• ENSP00000370010
• ENST00000451311
• ENSP00000414376

Symbol

• TB4X
• THYB4
• TMSB4
• FX
• TB4X
• PTMB4
• TMSB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	1
PubMedID	0.8
histone modification site profile	0.72
transcription factor binding site profile	0.69
biological term	0.68

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.24   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.24   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	1	1	0	1	5.2
asthma	EFO_0000270	1	1	0	1	3.9

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	0	1	5.2
asthma	EFO_0000270	0	1	3.9

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Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (8)

Reactome (4)

KEGG (1)

WikiPathways (3)

Hemostasis (R-HSA-109582)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Reactome	Platelet degranulation	128 targets	R-HSA-114608
Reactome	Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Platelet degranulation	128 targets	R-HSA-114608
Response to elevated platelet cytosolic Ca2+	133 targets	R-HSA-76005

Gene Ontology Terms (26)

Functions (3)

Components (7)

Processes (16)

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1 – 3 of 3

GO Term	Evidence	Assigned by
actin monomer binding	Inferred from Direct Assay (IDA)	CAFA
enzyme binding	Inferred from Physical Interaction (IPI)	CAFA
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (110)

Explore Interacting Targets

1 – 10 of 110

• See Interactions on String-DB

ACTA1

Tbio

Novelty: 0.00111813

Score: 0.98

Data Source: STRINGDB

ACTB

Tbio

Novelty: 0.00006048

Score: 0.971

Data Source: STRINGDB

ACTG1

Tbio

Novelty: 0.00086444

Score: 0.968

Data Source: STRINGDB

VEGFA

Tclin

Novelty: 0.0000378

Score: 0.958

Data Source: STRINGDB

PPBP

Tbio

Novelty: 0.00048307

Score: 0.924

Data Source: STRINGDB

SPARC

Tbio

Novelty: 0.00063267

Score: 0.923

Data Source: STRINGDB

PF4

Tbio

Novelty: 0.00038481

Score: 0.923

Data Source: STRINGDB

ACTN1

Tbio

Novelty: 0.00654004

Score: 0.922

Data Source: STRINGDB

FN1

Tchem

Novelty: 0.00003647

Score: 0.921

Data Source: STRINGDB

SERPINA1

Tbio

Novelty: 0.00014098

Score: 0.92

Data Source: STRINGDB

Publication Statistics

PubMed Score  580.24

PubMed score by year

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PubTator Score  250.63

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Isopeptide bond
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

asthma
childhood onset asthma

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype