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Tbio
TMSB4X
Thymosin beta-4

Protein Summary
Description
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380633
  • ENSP00000370007
  • ENSG00000205542
  • ENST00000380635
  • ENSP00000370009
  • ENST00000380636
  • ENSP00000370010
  • ENST00000451311
  • ENSP00000414376

Symbol
  • TB4X
  • THYB4
  • TMSB4
  • FX
  • TB4X
  • PTMB4
  • TMSB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
PubMedID
0.8
histone modification site profile
0.72
transcription factor binding site profile
0.69
biological term
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 596.57   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 596.57   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.98
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.971
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.968
Data Source:  STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.958
Data Source:  STRINGDB
PPBP
Tbio
Novelty:  0.00048307
Score:  0.924
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.923
Data Source:  STRINGDB
PF4
Tbio
Novelty:  0.00038481
Score:  0.923
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.922
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.921
Data Source:  STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1
12.2
1
1
0
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1
12.2
0
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99510
19241
Horse
thymosin beta 4, X-linked
100034015
Pig
thymosin beta 4, X-linked
733606
Anole lizard
thymosin beta 4, X-linked
100560572
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
thymosin beta 4, X-linked
Pig
thymosin beta 4, X-linked
Anole lizard
thymosin beta 4, X-linked
Publication Statistics
PubMed Score 596.57
PubMed score by year
PubTator Score 250.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title