TMSB4X
Thymosin beta-4
Protein Summary
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
- ENST00000380633
- ENSP00000370007
- ENSG00000205542
- ENST00000380635
- ENSP00000370009
- ENST00000380636
- ENSP00000370010
- ENST00000451311
- ENSP00000414376
- TB4X
- THYB4
- TMSB4
- FX
- TB4X
- PTMB4
- TMSB4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 1 | ||
PubMedID | 0.8 | ||
histone modification site profile | 0.72 | ||
transcription factor binding site profile | 0.69 | ||
biological term | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 610.49 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 610.49 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0