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Tbio
TMSB4X
Thymosin beta-4

Protein Summary
Description
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380633
  • ENSP00000370007
  • ENSG00000205542
  • ENST00000380635
  • ENSP00000370009
  • ENST00000380636
  • ENSP00000370010
  • ENST00000451311
  • ENSP00000414376

Symbol
  • TB4X
  • THYB4
  • TMSB4
  • FX
  • TB4X
  • PTMB4
  • TMSB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
PubMedID
0.8
histone modification site profile
0.72
transcription factor binding site profile
0.69
biological term
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.24   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.24   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1
5.2
1
1
0
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1
5.2
0
1
3.9
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (110)
1 – 10 of 110
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.98
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.971
Data Source: STRINGDB
ACTG1
Tbio
Novelty: 0.00086444
Score: 0.968
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.958
Data Source: STRINGDB
PPBP
Tbio
Novelty: 0.00048307
Score: 0.924
Data Source: STRINGDB
SPARC
Tbio
Novelty: 0.00063267
Score: 0.923
Data Source: STRINGDB
PF4
Tbio
Novelty: 0.00038481
Score: 0.923
Data Source: STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.922
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.921
Data Source: STRINGDB
SERPINA1
Tbio
Novelty: 0.00014098
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  580.24

PubMed score by year
PubTator Score  250.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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