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Tbio
BTG1
Protein BTG1

Protein Summary
Description
Anti-proliferative protein. This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256015
  • ENSP00000256015
  • ENSG00000133639

Symbol
  • APRO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.99
transcription factor perturbation
0.94
kinase perturbation
0.91
disease perturbation
0.9
PubMedID
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.07   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
92.8
eosinophil percentage of leukocytes
2
3
3
69.4
heel bone mineral density
1
1
1
54.4
sum of eosinophil and basophil counts
1
1
1
50.6
neutrophil percentage of granulocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
92.8
eosinophil percentage of leukocytes
3
69.4
heel bone mineral density
1
54.4
sum of eosinophil and basophil counts
1
50.6
neutrophil percentage of granulocytes
1
49.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88215
12226
Rat
RGD:2224
29618
Dog
BTG anti-proliferation factor 1
VGNC:38558
100684605
Horse
BTG anti-proliferation factor 1 [Source:HGNC Symbol;Acc:HGNC:1130]
Cow
BTG anti-proliferation factor 1
VGNC:26597
281032
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BTG anti-proliferation factor 1
Horse
BTG anti-proliferation factor 1 [Source:HGNC Symbol;Acc:HGNC:1130]
Cow
BTG anti-proliferation factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P62324-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell cycle genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of cell cycle genes
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
Score:  0.964
Data Source:  STRINGDB
CHAF1A
Tbio
Novelty:  0.02129179
Score:  0.9
Data Source:  STRINGDB
CHAF1B
Tbio
Novelty:  0.05899435
Score:  0.9
Data Source:  STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
Score:  0.838
Data Source:  STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
Score:  0.82
Data Source:  STRINGDB
HOXB9
Tbio
Family:  TF
Novelty:  0.01591519
Score:  0.639
Data Source:  STRINGDB
TLK2
Tchem
Family:  Kinase
Novelty:  0.07082609
Score:  0.613
Data Source:  STRINGDB
EIF3I
Tbio
Novelty:  0.04398155
Score:  0.571
Data Source:  STRINGDB
EIF3L
Tbio
Novelty:  0.11054104
Score:  0.564
Data Source:  STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
Score:  0.552
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.07

PubMed score by year
PubTator Score  60.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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