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Tbio
SNRPD3
Small nuclear ribonucleoprotein Sm D3

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215829
  • ENSP00000215829
  • ENSG00000100028
  • ENST00000402849
  • ENSP00000385266
  • ENST00000404603
  • ENSP00000456090

Symbol
  • SMD3
  • Sm-D3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.98
co-expressed gene
0.93
transcription factor binding site profile
0.9
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (462)
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.997901055
p_ni:  0.002098945
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.992102262
p_ni:  0.007897738
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.990408452
p_ni:  0.009591548
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.93980621
p_ni:  0.06019379
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.91371938
p_ni:  0.08628062
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.801693062
p_ni:  0.198306938
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.78133845
p_ni:  0.21866155
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.999
Data Source:  STRINGDB
LSM6
Tbio
Novelty:  0.09507671
Score:  0.999
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
19
20
9.5
99.9
liver fibrosis measurement
1
1
1
82.3
protein measurement
1
1
1
72.1
serum albumin measurement
1
1
1
72.1
creatinine measurement
1
1
1
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
20
9.5
99.9
liver fibrosis measurement
1
82.3
protein measurement
1
72.1
serum albumin measurement
1
72.1
creatinine measurement
1
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D3 polypeptide
VGNC:6007
100611816
Macaque
small nuclear ribonucleoprotein D3 polypeptide
708594
Mouse
MGI:1914582
67332
Dog
small nuclear ribonucleoprotein D3 polypeptide
607772
Horse
small nuclear ribonucleoprotein D3 polypeptide
VGNC:23400
100050121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D3 polypeptide
Macaque
small nuclear ribonucleoprotein D3 polypeptide
Mouse
Dog
small nuclear ribonucleoprotein D3 polypeptide
Horse
small nuclear ribonucleoprotein D3 polypeptide
Publication Statistics
PubMed Score 42.19
PubMed score by year
PubTator Score 25.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title