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Tbio
SNRPD2
Small nuclear ribonucleoprotein Sm D2

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342669
  • ENSP00000342374
  • ENSG00000125743
  • ENST00000391932
  • ENSP00000375798
  • ENST00000587367
  • ENSP00000465952
  • ENST00000588301
  • ENSP00000465216
  • ENST00000588599
  • ENSP00000466152

Symbol
  • SNRPD1
  • SMD2
  • Sm-D2
  • SNRPD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.97
kinase perturbation
0.95
histone modification site profile
0.93
protein complex
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
6
23
4.2
98.2
9
8
4
1.1
97.2
low density lipoprotein cholesterol measurement
2
4
5
96.5
apolipoprotein B measurement
2
3
4
94.9
total cholesterol measurement
1
3
3
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
23
4.2
98.2
4
1.1
97.2
low density lipoprotein cholesterol measurement
5
96.5
apolipoprotein B measurement
4
94.9
total cholesterol measurement
3
92.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D2 polypeptide
VGNC:2423
456134
Macaque
small nuclear ribonucleoprotein D2 polypeptide
715183
Mouse
MGI:98345
107686
Rat
RGD:1593018
680309
Dog
small nuclear ribonucleoprotein D2 polypeptide
VGNC:53987
100685983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein D2 polypeptide
Macaque
small nuclear ribonucleoprotein D2 polypeptide
Mouse
Rat
Dog
small nuclear ribonucleoprotein D2 polypeptide
Protein Structure (21 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62316-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (24)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (518)
1 – 10 of 518
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999952931
p_ni:  0.000047069
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999821877
p_ni:  0.000178123
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.999672926
p_ni:  0.000327074
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999428515
p_ni:  0.000571485
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.994752851
p_ni:  0.005247149
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
p_int:  0.99408594
p_ni:  0.00591406
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.993062926
p_ni:  0.006937074
Score:  0.999
Data Source:  BioPlex,STRINGDB
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.991674952
p_ni:  0.008325048
Score:  0.985
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.982684232
p_ni:  0.017315768
Score:  0.999
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.95917903
p_ni:  0.04082097
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.12

PubMed score by year
PubTator Score  34.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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