Tbio LSM6 U6 snRNA-associated Sm-like protein LSm6

Protein Summary

Description

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• P62312
• Q4W5J5
• Q9Y4Y8

Gene Name

• LSM6

Ensembl ID

• ENST00000296581
• ENSP00000296581
• ENSG00000164167
• ENST00000502781
• ENSP00000422392
• ENST00000504181
• ENSP00000420929
• ENST00000515311
• ENSP00000427036
• ENST00000649747
• ENSP00000497311

Symbol

• YDR378C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
interacting protein	0.84
cell type or tissue	0.75
transcription factor perturbation	0.74
tissue sample	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U6 Snrna-associated Sm-like Protein Lsm6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / U6 Snrna-associated Sm-like Protein Lsm6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0