Tbio SNRPG Small nuclear ribonucleoprotein G

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Small Nuclear Ribonucleoprotein G

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Small Nuclear Ribonucleoprotein G

Protein Summary

Description

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P62308
• D6W5G6
• Q15357
• Q6IB86
• snRNP-G

Gene Name

• SNRPG

Ensembl ID

• ENST00000272348
• ENSP00000272348
• ENSG00000143977

Symbol

• PBSCG
• SMG
• Sm-G

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.93
co-expressed gene	0.89
transcription factor perturbation	0.84
transcription factor binding site profile	0.79
tissue	0.72

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		90.6
alkaline phosphatase measurement	EFO_0004533	1	1	1		65.3
total cholesterol measurement	EFO_0004574	2	2	2		61.8
chronotype measurement	EFO_0008328	2	1	1	1	60.5
testosterone measurement	EFO_0004908	1	1	1		52.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		90.6
alkaline phosphatase measurement	EFO_0004533	1		65.3
total cholesterol measurement	EFO_0004574	2		61.8
chronotype measurement	EFO_0008328	1	1	60.5
testosterone measurement	EFO_0004908	1		52.7

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein polypeptide G	VGNC:380	736959
Macaque	small nuclear ribonucleoprotein polypeptide G		702586
Mouse	small nuclear ribonucleoprotein polypeptide G	MGI:1915261	68011
Rat	small nuclear ribonucleoprotein polypeptide G	RGD:1584713	681031
Dog	small nuclear ribonucleoprotein polypeptide G	VGNC:54547	612653

Species	Name	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein polypeptide G
Macaque	small nuclear ribonucleoprotein polypeptide G
Mouse	small nuclear ribonucleoprotein polypeptide G
Rat	small nuclear ribonucleoprotein polypeptide G
Dog	small nuclear ribonucleoprotein polypeptide G

Protein Structure (19 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62308-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (15)

Reactome (13)

KEGG (1)

WikiPathways (1)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Metabolism of non-coding RNA	53 targets	R-HSA-194441
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Metabolism of RNA	686 targets	R-HSA-8953854
Metabolism of non-coding RNA	53 targets	R-HSA-194441
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Processing of Capped Intronless Pre-mRNA	28 targets	R-HSA-75067

Gene Ontology Terms (27)

Functions (1)

Components (19)

Processes (7)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (544)

Explore Interacting Targets

1 – 10 of 544

• See Interactions on String-DB

SNRPB

Tbio

Novelty:  0.01503535

p_int:  0.966954107

p_ni:  0.033045893

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPC

Tbio

Novelty:  0.02049921

p_int:  0.925682463

p_ni:  0.074317537

Score:  0.999

Data Source:  BioPlex,STRINGDB

LSM3

Tbio

Novelty:  0.05044984

p_int:  0.820748804

p_ni:  0.179251196

Score:  0.999

Data Source:  BioPlex,STRINGDB

SNRPA1

Tbio

Novelty:  0.01232044

Score:  0.999

Data Source:  STRINGDB

LSM6

Tbio

Novelty:  0.09507671

Score:  0.999

Data Source:  STRINGDB

EFTUD2

Tbio

Novelty:  0.01805571

Score:  0.999

Data Source:  STRINGDB

LSM4

Tbio

Novelty:  0.00616897

Score:  0.999

Data Source:  STRINGDB

SNRPD2

Tbio

Novelty:  0.02519503

Score:  0.999

Data Source:  STRINGDB

SNRPB2

Tbio

Novelty:  0.17219587

Score:  0.999

Data Source:  STRINGDB

SNRPD1

Tbio

Novelty:  0.0136355

Score:  0.999

Data Source:  STRINGDB

Publication Statistics

PubMed Score  6.76

PubMed score by year

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PubTator Score  65.82

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
mRNA processing
mRNA splicing
Nucleus
Reference proteome
Ribonucleoprotein
RNA-binding
Spliceosome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
Alopecia
balding measurement
chronotype measurement
cognitive function measurement
low density lipoprotein cholesterol measurement
mathematical ability
self reported educational attainment
sex hormone-binding globulin measurement
testosterone measurement