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Tbio
SNRPG
Small nuclear ribonucleoprotein G

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272348
  • ENSP00000272348
  • ENSG00000143977

Symbol
  • PBSCG
  • SMG
  • Sm-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
co-expressed gene
0.89
transcription factor perturbation
0.84
transcription factor binding site profile
0.79
tissue
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
90.6
alkaline phosphatase measurement
1
1
1
65.3
total cholesterol measurement
2
2
2
61.8
chronotype measurement
2
1
1
1
60.5
testosterone measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
90.6
alkaline phosphatase measurement
1
65.3
total cholesterol measurement
2
61.8
chronotype measurement
1
1
60.5
testosterone measurement
1
52.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide G
VGNC:380
736959
Macaque
small nuclear ribonucleoprotein polypeptide G
702586
Mouse
MGI:1915261
68011
Rat
RGD:1584713
681031
Dog
small nuclear ribonucleoprotein polypeptide G
VGNC:54547
612653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein polypeptide G
Macaque
small nuclear ribonucleoprotein polypeptide G
Mouse
Rat
Dog
small nuclear ribonucleoprotein polypeptide G
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62308-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (544)
1 – 10 of 544
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.966954107
p_ni:  0.033045893
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
p_int:  0.925682463
p_ni:  0.074317537
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.820748804
p_ni:  0.179251196
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
Score:  0.999
Data Source:  STRINGDB
LSM6
Tbio
Novelty:  0.09507671
Score:  0.999
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.999
Data Source:  STRINGDB
LSM4
Tbio
Novelty:  0.00616897
Score:  0.999
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.999
Data Source:  STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
Score:  0.999
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.76

PubMed score by year
PubTator Score  65.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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