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Tbio
RPS11
40S ribosomal protein S11

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270625
  • ENSP00000270625
  • ENSG00000142534

Symbol
  • S11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
small molecule perturbation
0.85
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (543)
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.907191999
p_ni:  0.092731285
p_wrong:  0.000076717
Score:  0.215
Data Source:  BioPlex,STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.860870464
p_ni:  0.139126732
p_wrong:  0.000002804
Score:  0.23
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.826335648
p_ni:  0.173664352
Score:  0.928
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.811309877
p_ni:  0.188690123
Score:  0.998
Data Source:  BioPlex,STRINGDB
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.804773829
p_ni:  0.195226171
Data Source:  BioPlex
NAT10
Tbio
Family:  Enzyme
Novelty:  0.02453679
p_int:  0.752648044
p_ni:  0.247351956
Score:  0.825
Data Source:  BioPlex,STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.999
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.999
Data Source:  STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.999
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
10
11
99.4
serum albumin measurement
4
8
10
99.3
hemoglobin measurement
4
6
6
95.6
calcium measurement
1
4
4
95.1
hematocrit
4
5
6
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
11
99.4
serum albumin measurement
10
99.3
hemoglobin measurement
6
95.6
calcium measurement
4
95.1
hematocrit
6
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S11
748133
Macaque
ribosomal protein S11
718844
Mouse
MGI:1351329
27207
Rat
RGD:621026
81774
Dog
ribosomal protein S11
VGNC:53968
403684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S11
Macaque
ribosomal protein S11
Mouse
Rat
Dog
ribosomal protein S11
Publication Statistics
PubMed Score 51.03
PubMed score by year
PubTator Score 6.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title