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Tbio
RPS13
40S ribosomal protein S13

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525634
  • ENSP00000435777
  • ENSG00000110700

Symbol
  • S13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
small molecule perturbation
1
hub protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 830.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 830.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (629)
ZNF273
Tdark
Family:  TF
Novelty:  2.21830681
p_int:  0.999952519
p_ni:  0.000041203
p_wrong:  0.000006278
Data Source:  BioPlex
RIOK2
Tbio
Family:  Kinase
Novelty:  0.02940435
p_int:  0.999738679
p_ni:  0.000222687
p_wrong:  0.000038633
Score:  0.996
Data Source:  BioPlex,STRINGDB
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.998481299
p_ni:  0.00151852
p_wrong:  1.8e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
TUT7
Tbio
Family:  Enzyme
Novelty:  0.06274003
p_int:  0.997178793
p_ni:  0.002821207
Data Source:  BioPlex
RRP12
Tbio
Novelty:  0.10034381
p_int:  0.995514863
p_ni:  0.004485137
Score:  0.193
Data Source:  BioPlex,STRINGDB
KIF2A
Tbio
Novelty:  0.01463006
p_int:  0.994692397
p_ni:  0.00530744
p_wrong:  1.62e-7
Data Source:  BioPlex
BBX
Tbio
Family:  TF
Novelty:  0.02157387
p_int:  0.992992556
p_ni:  0.007007444
Data Source:  BioPlex
ASCC3
Tbio
Novelty:  0.1303631
p_int:  0.990597257
p_ni:  0.009402743
Data Source:  BioPlex
NOB1
Tbio
Novelty:  0.01209681
p_int:  0.990109904
p_ni:  0.009889201
p_wrong:  8.95e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
LTV1
Tbio
Novelty:  0.04050879
p_int:  0.990004315
p_ni:  0.009995685
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
3
5
94.7
1
1
0
1.2
89.3
2
1
1
1.2
76.8
ganglion cell inner plexiform layer thickness measurement
1
1
1
71.6
brain measurement
1
1
0
10.2
67
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
94.7
0
1.2
89.3
1
1.2
76.8
ganglion cell inner plexiform layer thickness measurement
1
71.6
brain measurement
0
10.2
67
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S13
697513
Mouse
MGI:1915302
68052
Horse
ribosomal protein S13
VGNC:22546
100056386
Cow
ribosomal protein S13
535668
Pig
ribosomal protein S13
100513520
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S13
Mouse
Horse
ribosomal protein S13
Cow
ribosomal protein S13
Pig
ribosomal protein S13
Publication Statistics
PubMed Score 830.31
PubMed score by year
PubTator Score 79.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title