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Tbio
RPS29
40S ribosomal protein S29

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245458
  • ENSP00000245458
  • ENSG00000213741
  • ENST00000396020
  • ENSP00000379339
  • ENST00000556230
  • ENSP00000495033

Symbol
  • S29
  • uS14
  • DBA13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
disease perturbation
0.97
interacting protein
0.97
kinase perturbation
0.97
gene perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (484)
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
RPLP0
Tbio
Novelty:  0.00398127
Score:  0.999
Data Source:  STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.999
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.999
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.999
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.999
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.999
Data Source:  STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.999
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.999
Data Source:  STRINGDB
RPS17
Tbio
Novelty:  0.00942675
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
60.1
self reported educational attainment
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
60.1
self reported educational attainment
1
3.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S29
107966486
Mouse
MGI:107681
20090
Horse
ribosomal protein S29
VGNC:22554
100051535
Cow
ribosomal protein S29
VGNC:34137
286884
Opossum
ribosomal protein S29 [Source:HGNC Symbol;Acc:HGNC:10419]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S29
Mouse
Horse
ribosomal protein S29
Cow
ribosomal protein S29
Opossum
ribosomal protein S29 [Source:HGNC Symbol;Acc:HGNC:10419]
Publication Statistics
PubMed Score 31.30
PubMed score by year
PubTator Score 21.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title