Tbio RPS18 40S ribosomal protein S18

Protein Summary

Description

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62269
• P25232
• Q5SUJ3
• Q6IPF8

Gene Name

• RPS18

Ensembl ID

• ENST00000211372
• ENSP00000211372
• ENSG00000096150
• ENST00000434122
• ENSP00000403175
• ENSG00000226225
• ENST00000439602
• ENSP00000393241
• ENSG00000231500
• ENST00000454021
• ENSP00000416110
• ENSG00000235650
• ENST00000457341
• ENSP00000412583
• ENSG00000223367

Symbol

• D6S218E
• KE3
• S18
• HKE3
• KE-3
• D6S218E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.99
disease perturbation	0.95
hub protein	0.85
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S18

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 40s Ribosomal Protein S18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.88   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.88   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0