RPS18
40S ribosomal protein S18
Protein Summary
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
- ENST00000211372
- ENSP00000211372
- ENSG00000096150
- ENST00000434122
- ENSP00000403175
- ENSG00000226225
- ENST00000439602
- ENSP00000393241
- ENSG00000231500
- ENST00000454021
- ENSP00000416110
- ENSG00000235650
- ENST00000457341
- ENSP00000412583
- ENSG00000223367
- D6S218E
- KE3
- S18
- HKE3
- KE-3
- D6S218E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 0.99 | ||
disease perturbation | 0.95 | ||
hub protein | 0.85 | ||
biological process | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.06 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.06 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (566)
Nearest Tclin Targets
Pathways (38)
Reactome (36)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (10)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (60)
Items per page:
1 – 5 of 60
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
Items per page:
1 – 5 of 60
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98146 | 20084 | ||||||
Rat | RGD:3595 | 294282 | ||||||
Dog | ribosomal protein S18 | VGNC:45733 | 403685 | |||||
Cow | ribosomal protein S18 | VGNC:54234 | 326602 | |||||
Pig | ribosomal protein S18 | 396980 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | ribosomal protein S18 | |||||
Cow | ribosomal protein S18 | |||||
Pig | ribosomal protein S18 | |||||
Publication Statistics
PubMed Score 125.06
PubMed score by year
PubTator Score 34.22
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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