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Tbio
RPS18
40S ribosomal protein S18

Protein Summary
Description
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211372
  • ENSP00000211372
  • ENSG00000096150
  • ENST00000434122
  • ENSP00000403175
  • ENSG00000226225
  • ENST00000439602
  • ENSP00000393241
  • ENSG00000231500
  • ENST00000454021
  • ENSP00000416110
  • ENSG00000235650
  • ENST00000457341
  • ENSP00000412583
  • ENSG00000223367

Symbol
  • D6S218E
  • KE3
  • S18
  • HKE3
  • KE-3
  • D6S218E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.99
disease perturbation
0.95
hub protein
0.85
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (566)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.993863998
p_ni:  0.006136002
Score:  0.243
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.844159691
p_ni:  0.155840309
Score:  0.236
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
Score:  0.999
Data Source:  STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.999
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.999
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.999
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.999
Data Source:  STRINGDB
RPL24
Tbio
Novelty:  0.02160548
Score:  0.999
Data Source:  STRINGDB
RPS27
Tchem
Novelty:  0.02805495
Score:  0.999
Data Source:  STRINGDB
RPS17
Tbio
Novelty:  0.00942675
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (60)
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98146
20084
Rat
RGD:3595
294282
Dog
ribosomal protein S18
VGNC:45733
403685
Cow
ribosomal protein S18
VGNC:54234
326602
Pig
ribosomal protein S18
396980
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ribosomal protein S18
Cow
ribosomal protein S18
Pig
ribosomal protein S18
Publication Statistics
PubMed Score 125.06
PubMed score by year
PubTator Score 34.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title