RPS23
40S ribosomal protein S23
Protein Summary
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692). Ribosomes, the organelles that catalyze protein synthesis, ...more
- ENST00000296674
- ENSP00000296674
- ENSG00000186468
- S23
- BTDD
- uS12
- MABAS
- MCINS
- PAMAS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.93 | ||
virus perturbation | 0.9 | ||
gene perturbation | 0.88 | ||
histone modification site profile | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.68 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.68 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (528)
Nearest Tclin Targets
Pathways (38)
Reactome (36)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 2 | 3 | 69.1 | |||||
cognitive function measurement | 3 | 1 | 3 | 53.7 | |||||
2 | 1 | 0 | 1.1 | 46.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 21.5 | |||||
carotid artery intima media thickness | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 69.1 | |||||
cognitive function measurement | 3 | 53.7 | |||||
0 | 1.1 | 46.9 | |||||
self reported educational attainment | 1 | 21.5 | |||||
carotid artery intima media thickness | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ribosomal protein S23 | VGNC:13582 | 461767 | |||||
Macaque | ribosomal protein S23 | 711914 | ||||||
Mouse | MGI:1913725 | 66475 | ||||||
Rat | RGD:621039 | 124323 | ||||||
Dog | ribosomal protein S23 | VGNC:53238 | 479159 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ribosomal protein S23 | |||||
Macaque | ribosomal protein S23 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribosomal protein S23 | |||||
Publication Statistics
PubMed Score 54.68
PubMed score by year
PubTator Score 24.40
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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