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Tbio
RPS23
40S ribosomal protein S23

Protein Summary
Description
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692). Ribosomes, the organelles that catalyze protein synthesis, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296674
  • ENSP00000296674
  • ENSG00000186468

Symbol
  • S23
  • BTDD
  • uS12
  • MABAS
  • MCINS
  • PAMAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.93
virus perturbation
0.9
gene perturbation
0.88
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (528)
RPS27L
Tbio
Novelty:  0.17169978
Score:  0.999
Data Source:  STRINGDB
RPS21
Tbio
Novelty:  0.00578555
Score:  0.999
Data Source:  STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.999
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.999
Data Source:  STRINGDB
RPL37
Tbio
Novelty:  0.03935854
Score:  0.999
Data Source:  STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
RPL6
Tbio
Novelty:  0.01742007
Score:  0.999
Data Source:  STRINGDB
RPL21
Tbio
Novelty:  0.01023355
Score:  0.999
Data Source:  STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
Score:  0.999
Data Source:  STRINGDB
RPL3L
Tbio
Novelty:  0.28678873
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
69.1
cognitive function measurement
3
1
3
53.7
2
1
0
1.1
46.9
self reported educational attainment
1
1
1
21.5
carotid artery intima media thickness
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
69.1
cognitive function measurement
3
53.7
0
1.1
46.9
self reported educational attainment
1
21.5
carotid artery intima media thickness
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S23
VGNC:13582
461767
Macaque
ribosomal protein S23
711914
Mouse
MGI:1913725
66475
Rat
RGD:621039
124323
Dog
ribosomal protein S23
VGNC:53238
479159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S23
Macaque
ribosomal protein S23
Mouse
Rat
Dog
ribosomal protein S23
Publication Statistics
PubMed Score 54.68
PubMed score by year
PubTator Score 24.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title