YWHAE
14-3-3 protein epsilon
Protein Summary
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript vari ...more
- ENST00000264335
- ENSP00000264335
- ENSG00000108953
- ENST00000571732
- ENSP00000461762
- ENST00000616643
- ENSP00000481059
- ENSG00000274474
- ENST00000627231
- ENSP00000487356
- MDS
- HEL2
- MDCR
- KCIP-1
- 14-3-3E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
protein complex | 0.99 | ||
virus perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.95 (req: < 5)
Gene RIFs: 96 (req: <= 3)
Antibodies: 442 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.95 (req: >= 5)
Gene RIFs: 96 (req: > 3)
Antibodies: 442 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0