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Tbio
UBE2H
Ubiquitin-conjugating enzyme E2 H

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355621
  • ENSP00000347836
  • ENSG00000186591
  • ENST00000473814
  • ENSP00000419097

Symbol
  • GID3
  • UBC8
  • UBCH
  • UBCH2
  • E2-20K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.96
molecular function
0.95
virus perturbation
0.88
transcription factor binding site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
UBA3
Tchem
Novelty:  0.03962261
Score:  0.989
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.986
Data Source:  STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
Score:  0.976
Data Source:  STRINGDB
UBE2J1
Tbio
Novelty:  0.03619613
Score:  0.972
Data Source:  STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
Score:  0.968
Data Source:  STRINGDB
UBE2J2
Tbio
Novelty:  0.2367348
Score:  0.964
Data Source:  STRINGDB
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
Score:  0.958
Data Source:  STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.958
Data Source:  STRINGDB
UBA7
Tbio
Novelty:  0.01923008
Score:  0.954
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
88.7
platelet crit
2
2
2
84.7
9
1
5
1.1
76.5
myeloid white cell count
1
1
1
72.6
leukocyte count
1
2
2
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
88.7
platelet crit
2
84.7
5
1.1
76.5
myeloid white cell count
1
72.6
leukocyte count
2
72.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 H
VGNC:4555
741944
Macaque
ubiquitin conjugating enzyme E2 H
702056
Mouse
MGI:104632
22214
Rat
RGD:2319288
296956
Dog
ubiquitin conjugating enzyme E2 H
VGNC:48054
607816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 H
Macaque
ubiquitin conjugating enzyme E2 H
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 H
Publication Statistics
PubMed Score 28.09
PubMed score by year
PubTator Score 13.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title