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Tbio
RPS16
40S ribosomal protein S16

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251453
  • ENSP00000251453
  • ENSG00000105193

Symbol
  • S16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.99
hub protein
0.95
transcription factor binding site profile
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.64   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.64   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (613)
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
p_int:  0.999987655
p_ni:  0.000012345
Data Source:  BioPlex
RIOK2
Tbio
Family:  Kinase
Novelty:  0.02940435
p_int:  0.999982392
p_ni:  0.000017607
Score:  0.989
Data Source:  BioPlex,STRINGDB
SRFBP1
Tbio
Novelty:  0.10070972
p_int:  0.999980266
p_ni:  0.000016311
p_wrong:  0.000003423
Data Source:  BioPlex
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
p_int:  0.999946265
p_ni:  0.000053226
p_wrong:  5.09e-7
Data Source:  BioPlex
SRBD1
Tbio
Novelty:  0.18931356
p_int:  0.999826968
p_ni:  0.000173032
Data Source:  BioPlex
CMSS1
Tdark
Novelty:  0.21418543
p_int:  0.999765145
p_ni:  0.000220685
p_wrong:  0.000014169
Data Source:  BioPlex
TBC1D17
Tdark
Novelty:  0.64376132
p_int:  0.999616519
p_ni:  0.000382663
p_wrong:  8.19e-7
Data Source:  BioPlex
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
p_int:  0.999338835
p_ni:  0.000661137
p_wrong:  2.9e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.999132565
p_ni:  0.000867428
p_wrong:  8e-9
Data Source:  BioPlex
RBM19
Tbio
Novelty:  0.15784228
p_int:  0.999119501
p_ni:  0.000880499
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (202)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S16
697219
Mouse
MGI:98118
20055
Rat
RGD:621031
140655
Dog
ribosomal protein S16
VGNC:45732
476463
Horse
ribosomal protein S16
VGNC:22549
100064489
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S16
Mouse
Rat
Dog
ribosomal protein S16
Horse
ribosomal protein S16
Publication Statistics
PubMed Score 400.64
PubMed score by year
PubTator Score 128.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title