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Tbio
RPS15A
40S ribosomal protein S15a

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322989
  • ENSP00000318646
  • ENSG00000134419
  • ENST00000563390
  • ENSP00000457000
  • ENST00000565420
  • ENSP00000458115
  • ENST00000572008
  • ENSP00000458528

Symbol
  • S15a
  • DBA20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.97
microRNA
0.9
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
35
mean platelet volume
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
35
mean platelet volume
1
6.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S15a
100614776
Macaque
ADP ribosylation factor like GTPase 6 interacting protein 1
693296
Mouse
MGI:2389091
267019
Rat
RGD:619939
117053
Horse
ribosomal protein S15a
VGNC:22548
100630410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S15a
Macaque
ADP ribosylation factor like GTPase 6 interacting protein 1
Mouse
Rat
Horse
ribosomal protein S15a
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (521)
1 – 10 of 521
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.79521316
p_ni:  0.20478684
Score:  0.545
Data Source:  BioPlex,STRINGDB
RPS7
Tbio
Novelty:  0.00745987
p_int:  0.755491985
p_ni:  0.244508015
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL7
Tbio
Novelty:  0.00552644
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
RPL13
Tbio
Novelty:  0.0159486
Score:  0.999
Data Source:  STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
Score:  0.999
Data Source:  STRINGDB
RPS28
Tbio
Novelty:  0.03303065
Score:  0.999
Data Source:  STRINGDB
RPLP1
Tbio
Novelty:  0.01471148
Score:  0.999
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  34.52

PubMed score by year
PubTator Score  13.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer