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Tbio
PSMC5
26S proteasome regulatory subunit 8

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310144
  • ENSP00000310572
  • ENSG00000087191
  • ENST00000375812
  • ENSP00000364970
  • ENST00000580864
  • ENSP00000462495
  • ENST00000581882
  • ENSP00000463938

Symbol
  • SUG1
  • S8
  • p45
  • SUG1
  • SUG-1
  • TBP10
  • TRIP1
  • p45/SUG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
viral protein
1
kinase perturbation
0.99
molecular function
0.99
disease perturbation
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.84   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.84   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (492)
CEP83
Tdark
Novelty:  0.15704554
p_int:  0.999997868
p_ni:  0.000002132
Data Source:  BioPlex
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.999994768
p_ni:  0.000005232
Score:  0.999
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999994547
p_ni:  0.000005453
Data Source:  BioPlex
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999989549
p_ni:  0.000010451
Score:  0.999
Data Source:  BioPlex,STRINGDB
RUNX1T1
Tbio
Novelty:  0.0039633
p_int:  0.999988223
p_ni:  0.000011775
p_wrong:  2e-9
Score:  0.156
Data Source:  BioPlex,STRINGDB
SSNA1
Tbio
Novelty:  0.02189473
p_int:  0.999985034
p_ni:  0.000014947
p_wrong:  1.9e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
ABRAXAS1
Tbio
Novelty:  0.07078408
p_int:  0.999969418
p_ni:  0.000030582
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999910284
p_ni:  0.000089716
Data Source:  BioPlex
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.999904773
p_ni:  0.000095223
p_wrong:  4e-9
Data Source:  BioPlex
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
p_int:  0.999879597
p_ni:  0.000120403
Score:  0.203
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (165)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
98.4
body height
7
7
9
97.5
BMI-adjusted hip circumference
3
5
6
92.3
appendicular lean mass
2
2
4
91.1
hematocrit
2
2
2
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
98.4
body height
9
97.5
BMI-adjusted hip circumference
6
92.3
appendicular lean mass
4
91.1
hematocrit
2
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 5
VGNC:9542
454777
Macaque
proteasome 26S subunit, ATPase 5
717437
Mouse
MGI:105047
19184
Rat
RGD:708376
81827
Horse
proteasome 26S subunit, ATPase 5
VGNC:21954
100053987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 5
Macaque
proteasome 26S subunit, ATPase 5
Mouse
Rat
Horse
proteasome 26S subunit, ATPase 5
Publication Statistics
PubMed Score 62.84
PubMed score by year
PubTator Score 30.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title