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Tbio
NCS1
Neuronal calcium sensor 1

Protein Summary
Description
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372398
  • ENSP00000361475
  • ENSG00000107130
  • ENST00000630865
  • ENSP00000486695

Symbol
  • FLUP
  • FREQ
  • FLUP
  • FREQ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor perturbation
0.88
virus perturbation
0.85
small molecule perturbation
0.8
microRNA
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.45   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.45   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
2
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
7.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109166
14299
Rat
RGD:68417
65153
Dog
neuronal calcium sensor 1
VGNC:43667
491294
Horse
neuronal calcium sensor 1
VGNC:20605
100069825
Cow
neuronal calcium sensor 1
VGNC:31928
526544
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
neuronal calcium sensor 1
Horse
neuronal calcium sensor 1
Cow
neuronal calcium sensor 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62166-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (81)
1 – 10 of 81
BSPRY
Tdark
Novelty: 0.38200913
p_int: 0.999999956
p_ni: 4.4e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
ABHD6
Tchem
Family: Enzyme
Novelty: 0.019314
p_int: 0.999998747
p_ni: 0.000001253
Score: 0.228
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.999982997
p_ni: 0.000017003
Score: 0.181
Data Source: BioPlex,STRINGDB
USP24
Tbio
Family: Enzyme
Novelty: 0.07281326
p_int: 0.99996608
p_ni: 0.00003392
Score: 0.17
Data Source: BioPlex,STRINGDB
TK1
Tchem
Family: Kinase
Novelty: 0.00139343
p_int: 0.999781926
p_ni: 0.000218074
Score: 0.163
Data Source: BioPlex,STRINGDB
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.999150144
p_ni: 0.000849856
Score: 0.286
Data Source: BioPlex,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.993454487
p_ni: 0.006545513
Data Source: BioPlex
FBXL22
Tdark
Novelty: 0.59436124
p_int: 0.927242134
p_ni: 0.0727573
p_wrong: 5.66e-7
Data Source: BioPlex
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.911046201
p_ni: 0.088953799
Score: 0.163
Data Source: BioPlex,STRINGDB
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
p_int: 0.868502955
p_ni: 0.13147851
p_wrong: 0.000018535
Score: 0.234
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  233.45

PubMed score by year
PubTator Score  133.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer