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Tbio
PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Protein Summary
Description
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). The pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296122
  • ENSP00000296122
  • ENSG00000213639
  • ENST00000358506
  • ENSP00000351298
  • ENST00000395366
  • ENSP00000378769

Symbol
  • PP1B
  • NSLH2
  • PP-1B
  • PPP1CD
  • PP1beta
  • HEL-S-80p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
transcription factor binding site profile
0.89
virus perturbation
0.88
kinase perturbation
0.84
biological process
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.11   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.11   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
74.3
HIV-1 infection
1
1
1
64.4
viral load
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
74.3
HIV-1 infection
1
64.4
viral load
1
64.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 catalytic subunit beta
VGNC:7699
459118
Mouse
MGI:104871
19046
Rat
RGD:3376
25594
Dog
protein phosphatase 1 catalytic subunit beta
VGNC:44875
403558
Horse
protein phosphatase 1 catalytic subunit beta
VGNC:21752
100071067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 catalytic subunit beta
Mouse
Rat
Dog
protein phosphatase 1 catalytic subunit beta
Horse
protein phosphatase 1 catalytic subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P62140-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Circadian Clock
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
G2/M Transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Circadian Clock
Downregulation of TGF-beta receptor signaling
G2/M Transition
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (332)
1 – 10 of 332
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999725523
p_ni: 0.000274477
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
PPP1R16B
Tbio
Family: Enzyme
Novelty: 0.08773047
p_int: 0.998926515
p_ni: 0.001073485
Score: 0.944
Data Source: BioPlex,STRINGDB
PPP1R18
Tbio
Novelty: 0.18837599
p_int: 0.982840714
p_ni: 0.017159286
Score: 0.869
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.973721765
p_ni: 0.026278235
Score: 0.988
Data Source: BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty: 0.03903985
p_int: 0.960395868
p_ni: 0.039604132
Score: 0.252
Data Source: BioPlex,STRINGDB
TPRN
Tbio
Novelty: 0.05784581
p_int: 0.954664761
p_ni: 0.045335239
Score: 0.86
Data Source: BioPlex,STRINGDB
SH2D4A
Tbio
Novelty: 0.12343277
p_int: 0.947007934
p_ni: 0.052992066
Score: 0.847
Data Source: BioPlex,STRINGDB
CSRNP1
Tbio
Novelty: 0.10538864
p_int: 0.837038839
p_ni: 0.162961161
Data Source: BioPlex
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.828594272
p_ni: 0.171405728
Score: 0.998
Data Source: BioPlex,STRINGDB
INTS1
Tbio
Novelty: 0.17523407
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.11

PubMed score by year
PubTator Score  36.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer