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Tchem
PPP1CA
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Protein Summary
Description
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312989
  • ENSP00000326031
  • ENSG00000172531
  • ENST00000358239
  • ENSP00000350974
  • ENST00000376745
  • ENSP00000365936

Symbol
  • PPP1A
  • PP1A
  • PP-1A
  • PPP1A
  • PP1alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
0.96
disease perturbation
0.95
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.01   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.01   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
54.5
body height
1
1
1
32.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
54.5
body height
1
32.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 catalytic subunit alpha
VGNC:13321
745709
Macaque
protein phosphatase 1 catalytic subunit alpha
721735
Mouse
MGI:103016
19045
Rat
RGD:3375
24668
Horse
protein phosphatase 1 catalytic subunit alpha
VGNC:49522
100059233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 catalytic subunit alpha
Macaque
protein phosphatase 1 catalytic subunit alpha
Mouse
Rat
Horse
protein phosphatase 1 catalytic subunit alpha
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62136-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (75)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
DARPP-32 events
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Circadian Clock
DARPP-32 events
Downregulation of TGF-beta receptor signaling
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (42)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (438)
1 – 10 of 438
PPP1R8
Tbio
Family: Enzyme
Novelty: 0.00138054
p_int: 1
Score: 0.982
Data Source: BioPlex,STRINGDB
PPP1R18
Tbio
Novelty: 0.18837599
p_int: 1
Score: 0.967
Data Source: BioPlex,STRINGDB
PPP1R37
Tdark
Family: Enzyme
Novelty: 2.23352303
p_int: 1
Score: 0.206
Data Source: BioPlex,STRINGDB
TPRN
Tbio
Novelty: 0.05784581
p_int: 0.999999999
p_ni: 1e-9
Score: 0.335
Data Source: BioPlex,STRINGDB
PPP1R11
Tbio
Family: Enzyme
Novelty: 0.08166535
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.958
Data Source: BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty: 0.00565862
p_int: 0.999999995
p_ni: 5e-9
Score: 0.931
Data Source: BioPlex,Reactome,STRINGDB
PPP1R9A
Tbio
Novelty: 0.04851082
p_int: 0.999999994
p_ni: 6e-9
Score: 0.883
Data Source: BioPlex,STRINGDB
PPP1R13L
Tbio
Novelty: 0.01378765
p_int: 0.999999992
p_ni: 1e-9
p_wrong: 7e-9
Score: 0.327
Data Source: BioPlex,STRINGDB
SHOC2
Tbio
Novelty: 0.01203957
p_int: 0.999999989
p_ni: 1e-9
p_wrong: 1e-8
Score: 0.968
Data Source: BioPlex,STRINGDB
PLCL2
Tbio
Family: Enzyme
Novelty: 0.13454277
p_int: 0.999999973
p_ni: 3e-9
p_wrong: 2.3e-8
Score: 0.582
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  257.01

PubMed score by year
PubTator Score  93.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer