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Tbio
RPS7
40S ribosomal protein S7

Protein Summary
Description
Required for rRNA maturation. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304921
  • ENSP00000339095
  • ENSG00000171863
  • ENST00000403564
  • ENSP00000385018
  • ENST00000406376
  • ENSP00000385286
  • ENST00000462576
  • ENSP00000495273
  • ENST00000645674
  • ENSP00000496757
  • ENST00000646909
  • ENSP00000496654

Symbol
  • S7
  • eS7
  • DBA8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
small molecule perturbation
1
hub protein
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.11   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.11   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (509)
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.96638934
p_ni:  0.03361066
Score:  0.995
Data Source:  BioPlex,STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.959489475
p_ni:  0.040390476
p_wrong:  0.000120049
Score:  0.599
Data Source:  BioPlex,STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.941999332
p_ni:  0.057910426
p_wrong:  0.000090242
Score:  0.158
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.847359013
p_ni:  0.152640987
Score:  0.999
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.832980572
p_ni:  0.167019428
Data Source:  BioPlex
RPL5
Tbio
Novelty:  0.00663792
p_int:  0.790693067
p_ni:  0.209306933
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
p_int:  0.755491985
p_ni:  0.244508015
Score:  0.999
Data Source:  BioPlex,STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.999
Data Source:  STRINGDB
RPL15
Tbio
Novelty:  0.02466708
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
82.9
low density lipoprotein cholesterol measurement
4
4
4
78.2
high density lipoprotein cholesterol measurement
3
2
3
77.8
apolipoprotein A 1 measurement
2
2
2
75
viral load
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
82.9
low density lipoprotein cholesterol measurement
4
78.2
high density lipoprotein cholesterol measurement
3
77.8
apolipoprotein A 1 measurement
2
75
viral load
1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S7
VGNC:10753
100614560
Macaque
ribosomal protein S7
721900
Mouse
MGI:1333818
20115
Rat
RGD:61907
29258
Dog
ribosomal protein S7
VGNC:45748
475649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S7
Macaque
ribosomal protein S7
Mouse
Rat
Dog
ribosomal protein S7
Publication Statistics
PubMed Score 120.11
PubMed score by year
PubTator Score 29.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title