You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TSPAN5
Tetraspanin-5

Protein Summary
Description
Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305798
  • ENSP00000307701
  • ENSG00000168785

Symbol
  • TM4SF9
  • NET4
  • NET-4
  • TM4SF9
  • TSPAN-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
trait
0.93
disease perturbation
0.87
virus perturbation
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
7
8
93.1
alcohol use disorder measurement
1
1
0
1.2
3.9
1
1
0
1.2
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
8
93.1
alcohol use disorder measurement
0
1.2
3.9
0
1.2
3.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 5
VGNC:12872
461390
Macaque
tetraspanin 5
706537
Mouse
MGI:1928096
56224
Rat
RGD:1303176
362048
Dog
tetraspanin 5
VGNC:47923
478486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 5
Macaque
tetraspanin 5
Mouse
Rat
Dog
tetraspanin 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P62079-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (65)
1 – 10 of 65
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999753
p_ni:  2.47e-7
Data Source:  BioPlex
TMEM248
Tdark
Novelty:  2.69323589
p_int:  0.999998867
p_ni:  6.46e-7
p_wrong:  4.87e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
NAT8L
Tbio
Family:  Enzyme
Novelty:  0.01761988
p_int:  0.999996838
p_ni:  0.000003155
p_wrong:  7e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
IMMP1L
Tbio
Family:  Enzyme
Novelty:  0.16680031
p_int:  0.999988855
p_ni:  2.4e-7
p_wrong:  0.000010905
Score:  0.189
Data Source:  BioPlex,STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.999987899
p_ni:  0.000012099
p_wrong:  2e-9
Data Source:  BioPlex
SNX25
Tbio
Novelty:  0.15818269
p_int:  0.999940052
p_ni:  0.000059939
p_wrong:  9e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
MRM2
Tbio
Family:  Enzyme
Novelty:  0.06394065
p_int:  0.999886932
p_ni:  0.000113064
p_wrong:  4e-9
Data Source:  BioPlex
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.999752837
p_ni:  0.000246285
p_wrong:  8.78e-7
Data Source:  BioPlex
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999579144
p_ni:  1.59e-7
p_wrong:  0.000420696
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999561231
p_ni:  0.000438768
p_wrong:  2e-9
Score:  0.263
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.11

PubMed score by year
PubTator Score  44.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer