Tbio TSPAN5 Tetraspanin-5

Protein Summary

Description

Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62079
• B2RDY2
• O60628
• O60746
• Q6FHE5
• Q9JLY1
• Tspan-5

Gene Name

• TSPAN5

Ensembl ID

• ENST00000305798
• ENSP00000307701
• ENSG00000168785

Symbol

• TM4SF9
• NET4
• NET-4
• TM4SF9
• TSPAN-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
trait	0.93
disease perturbation	0.87
virus perturbation	0.83
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.86   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0