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Tbio
TIMM10
Mitochondrial import inner membrane translocase subunit Tim10

Protein Classes
Protein Summary
Description
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257245
  • ENSP00000257245
  • ENSG00000134809
  • ENST00000525158
  • ENSP00000433627
  • ENST00000525587
  • ENSP00000435678

Symbol
  • TIM10
  • TIM10
  • TIM10A
  • TIMM10A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.88
transcription factor binding site profile
0.84
disease perturbation
0.83
cell type or tissue
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.1
platelet count
1
1
1
66.3
1
1
1
51.7
mathematical ability
2
1
2
49.5
neuroticism measurement
1
2
0
5.8
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.1
platelet count
1
66.3
1
51.7
mathematical ability
2
49.5
neuroticism measurement
0
5.8
36.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 10
VGNC:53173
451194
Mouse
MGI:1353429
30059
Rat
RGD:621741
64464
Dog
translocase of inner mitochondrial membrane 10
VGNC:49618
475968
Horse
translocase of inner mitochondrial membrane 10
VGNC:50501
100066829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 10
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 10
Horse
translocase of inner mitochondrial membrane 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62072-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (214)
1 – 10 of 214
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
p_int:  0.999999949
p_ni:  2e-9
p_wrong:  4.9e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.999985485
p_ni:  0.000014515
Score:  0.857
Data Source:  BioPlex,STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
p_int:  0.999965209
p_ni:  0.000034791
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACAD10
Tchem
Family:  Enzyme
Novelty:  0.09858243
p_int:  0.999558883
p_ni:  0.000441117
Data Source:  BioPlex
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
p_int:  0.998609195
p_ni:  0.001390805
Score:  0.544
Data Source:  BioPlex,STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
p_int:  0.998270141
p_ni:  0.001578371
p_wrong:  0.000151487
Data Source:  BioPlex
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
p_int:  0.995815492
p_ni:  0.00418437
p_wrong:  1.38e-7
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.985219885
p_ni:  0.014780104
p_wrong:  1.1e-8
Data Source:  BioPlex
MTMR6
Tbio
Family:  Enzyme
Novelty:  0.13067072
p_int:  0.982718774
p_ni:  0.01726344
p_wrong:  0.000017786
Data Source:  BioPlex
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.9795414
p_ni:  0.0204586
Score:  0.968
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.36

PubMed score by year
PubTator Score  15.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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