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Tbio
USP46
Ubiquitin carboxyl-terminal hydrolase 46

Protein Summary
Description
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000441222
  • ENSP00000407818
  • ENSG00000109189
  • ENST00000508499
  • ENSP00000423244
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
histone modification site profile
0.84
co-expressed gene
0.79
disease perturbation
0.74
microRNA
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 46
698618
Mouse
MGI:1916977
69727
Rat
RGD:1564808
289584
Dog
ubiquitin specific peptidase 46
VGNC:51784
475142
Horse
ubiquitin specific peptidase 46
VGNC:51344
100060432
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 46
Mouse
Rat
Dog
ubiquitin specific peptidase 46
Horse
ubiquitin specific peptidase 46
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62068-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (66)
1 – 10 of 66
WDR20
Tbio
Novelty: 0.03031804
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
PHLPP2
Tbio
Family: Enzyme
Novelty: 0.02479769
p_int: 0.999999987
p_ni: 6e-9
p_wrong: 7e-9
Score: 0.757
Data Source: BioPlex,STRINGDB
DMWD
Tbio
Novelty: 0.04096001
p_int: 0.99999949
p_ni: 5.1e-7
Score: 0.74
Data Source: BioPlex,STRINGDB
RAD51AP1
Tbio
Novelty: 0.04859066
p_int: 0.999990973
p_ni: 0.000009026
Score: 0.765
Data Source: BioPlex,STRINGDB
PHLPP1
Tchem
Family: Enzyme
Novelty: 0.00747239
p_int: 0.999989802
p_ni: 0.000010186
p_wrong: 1.2e-8
Score: 0.835
Data Source: BioPlex,STRINGDB
TSPYL6
Tdark
Novelty: 0.68478376
p_int: 0.99998052
p_ni: 0.000019478
p_wrong: 2e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
GORASP1
Tbio
Novelty: 0.02332405
p_int: 0.999947185
p_ni: 0.000052811
p_wrong: 5e-9
Data Source: BioPlex
WDR48
Tbio
Novelty: 0.04070481
p_int: 0.999747605
p_ni: 0.000252395
Score: 0.999
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.998866017
p_ni: 0.000982289
p_wrong: 0.000151694
Data Source: BioPlex
THUMPD3
Tdark
Novelty: 0.23224828
p_int: 0.998528274
p_ni: 0.000921988
p_wrong: 0.000549737
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  23.57

PubMed score by year
PubTator Score  11.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer