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Tbio
NUTF2
Nuclear transport factor 2

Protein Summary
Description
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219169
  • ENSP00000219169
  • ENSG00000102898
  • ENST00000568396
  • ENSP00000457022
  • ENST00000569436
  • ENSP00000457989

Symbol
  • NTF2
  • NTF2
  • PP15
  • NTF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.91
kinase perturbation
0.88
PubMedID
0.75
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
4
96.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
96.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2
VGNC:13755
454177
Macaque
nuclear transport factor 2
700488
Mouse
MGI:1915301
68051
Rat
RGD:1359213
291981
Horse
nuclear transport factor 2
VGNC:20981
100053553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2
Macaque
nuclear transport factor 2
Mouse
Rat
Horse
nuclear transport factor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P61970-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Posttranslational regulation of adherens junction stability and dissassembly
Name
Explore in Pharos
Explore in Source
Posttranslational regulation of adherens junction stability and dissassembly
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (152)
1 – 10 of 152
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
p_int: 0.995400976
p_ni: 0.004599024
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
Score: 0.998
Data Source: STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.00917672
Score: 0.988
Data Source: STRINGDB
NUP153
Tbio
Novelty: 0.00696568
Score: 0.988
Data Source: STRINGDB
RCC1
Tbio
Novelty: 0.00260884
Score: 0.986
Data Source: STRINGDB
RANBP1
Tbio
Family: Enzyme
Novelty: 0.01208948
Score: 0.984
Data Source: STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.982
Data Source: STRINGDB
NUP214
Tbio
Novelty: 0.00924336
Score: 0.978
Data Source: STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
Score: 0.977
Data Source: STRINGDB
KPNA2
Tbio
Novelty: 0.00506958
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  316.40

PubMed score by year
PubTator Score  311.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer