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Tbio
LMO4
LIM domain transcription factor LMO4

Protein Summary
Description
Probable transcriptional factor. This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370542
  • ENSP00000359573
  • ENSG00000143013
  • ENST00000370544
  • ENSP00000359575
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.98
kinase perturbation
0.93
transcription factor
0.84
cell type or tissue
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.19   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.19   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
SSBP2
Tbio
Novelty:  0.06546999
p_int:  0.999992709
p_ni:  0.000001673
p_wrong:  0.000005618
Score:  0.87
Data Source:  BioPlex,STRINGDB
IDI2
Tbio
Family:  Enzyme
Novelty:  0.02715208
p_int:  0.99998866
p_ni:  7.43e-7
p_wrong:  0.000010597
Score:  0.86
Data Source:  BioPlex,STRINGDB
SSBP4
Tdark
Novelty:  0.27365687
p_int:  0.999986736
p_ni:  2.4e-8
p_wrong:  0.00001324
Score:  0.871
Data Source:  BioPlex,STRINGDB
SSBP3
Tbio
Novelty:  0.01955714
p_int:  0.999358789
p_ni:  5.22e-7
p_wrong:  0.000640689
Score:  0.873
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
Score:  0.958
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.928
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.928
Data Source:  STRINGDB
FOXO1
Tbio
Family:  TF
Novelty:  0.00058938
Score:  0.91
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.907
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
IL6-mediated signaling events
PathwayCommons: pid
Validated nuclear estrogen receptor alpha network
PathwayCommons: pid
SHP2 signaling
Name
Explore in Pharos
Explore in Source
IL6-mediated signaling events
Validated nuclear estrogen receptor alpha network
SHP2 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
4
3
4
90.2
eosinophil count
4
2
4
81.5
eosinophil percentage of leukocytes
2
2
2
80.2
age at first sexual intercourse measurement
1
1
1
17.8
basophil percentage of leukocytes
1
1
1
17.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
4
90.2
eosinophil count
4
81.5
eosinophil percentage of leukocytes
2
80.2
age at first sexual intercourse measurement
1
17.8
basophil percentage of leukocytes
1
17.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 4
VGNC:11517
737619
Macaque
LIM domain only 4
712752
Mouse
MGI:109360
16911
Rat
RGD:1305670
362051
Dog
LIM domain only 4
VGNC:42724
479962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 4
Macaque
LIM domain only 4
Mouse
Rat
Dog
LIM domain only 4
Publication Statistics
PubMed Score 15.19
PubMed score by year
PubTator Score 44.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title