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Tchem
WDR5
WD repeat-containing protein 5

Protein Summary
Description
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358625
  • ENSP00000351446
  • ENSG00000196363

Symbol
  • BIG3
  • SWD3
  • BIG-3
  • CFAP89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.98
kinase perturbation
0.95
molecular function
0.86
hub protein
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.49   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.49   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (388)
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
p_int:  1
Score:  0.995
Data Source:  BioPlex,STRINGDB
ATN1
Tbio
Novelty:  0.01227042
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.273
Data Source:  BioPlex,STRINGDB
KANSL1
Tbio
Novelty:  0.03032662
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
p_int:  0.999999985
p_ni:  6e-9
p_wrong:  9e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
PAXIP1
Tbio
Novelty:  0.01728724
p_int:  0.999999843
p_ni:  1.57e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
RERE
Tbio
Family:  TF
Novelty:  0.03065098
p_int:  0.999999829
p_ni:  2e-9
p_wrong:  1.69e-7
Score:  0.75
Data Source:  BioPlex,STRINGDB
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.999999811
p_ni:  1.89e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.999999771
p_ni:  2.29e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Chromatin modifying enzymes
Chromatin organization
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
4
6
96.3
platelet count
3
3
2
3
94.4
reticulocyte count
7
4
13
93.3
mean platelet volume
2
3
4
93.1
eosinophil percentage of leukocytes
2
2
2
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
6
96.3
platelet count
2
3
94.4
reticulocyte count
13
93.3
mean platelet volume
4
93.1
eosinophil percentage of leukocytes
2
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 5
VGNC:14475
746901
Macaque
WD repeat domain 5
722123
Mouse
MGI:2155884
140858
Rat
RGD:1305159
362093
Dog
WD repeat domain 5
VGNC:48373
608113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 5
Macaque
WD repeat domain 5
Mouse
Rat
Dog
WD repeat domain 5
Publication Statistics
PubMed Score 176.49
PubMed score by year
PubTator Score 92.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title