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Tbio
DCAF7
DDB1- and CUL4-associated factor 7

Protein Summary
Description
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415273
  • ENSP00000403920
  • ENSG00000136485
  • ENST00000431926
  • ENSP00000402312
  • ENST00000614556
  • ENSP00000483236

Symbol
  • HAN11
  • WDR68
  • AN11
  • HAN11
  • WDR68
  • SWAN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
microRNA
0.82
transcription factor binding site profile
0.78
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
21.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 7
720299
Mouse
MGI:1919083
71833
Rat
RGD:1305140
303602
Dog
DDB1 and CUL4 associated factor 7
VGNC:39796
100856670
Horse
DDB1 and CUL4 associated factor 7
VGNC:17033
100054273
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DDB1 and CUL4 associated factor 7
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 7
Horse
DDB1 and CUL4 associated factor 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P61962-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (11)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (155)
1 – 10 of 155
SOWAHC
Tdark
Novelty: 0.68021562
p_int: 0.999999991
p_wrong: 9e-9
Score: 0.351
Data Source: BioPlex,STRINGDB
FBRSL1
Tdark
Novelty: 0.53733998
p_int: 0.999999963
p_ni: 1e-8
p_wrong: 2.7e-8
Score: 0.808
Data Source: BioPlex,STRINGDB
SOWAHA
Tdark
Novelty: 1.30261993
p_int: 0.999999961
p_ni: 7e-9
p_wrong: 3.1e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
RNF169
Tbio
Family: Enzyme
Novelty: 0.28921437
p_int: 0.999999885
p_ni: 1.15e-7
p_wrong: 1e-9
Score: 0.362
Data Source: BioPlex,STRINGDB
DYRK1B
Tchem
Family: Kinase
Novelty: 0.01960932
p_int: 0.999999638
p_ni: 1.18e-7
p_wrong: 2.44e-7
Score: 0.992
Data Source: BioPlex,STRINGDB
TROAP
Tbio
Novelty: 0.06268103
p_int: 0.999999532
p_ni: 4.67e-7
Score: 0.168
Data Source: BioPlex,STRINGDB
ZNF703
Tbio
Novelty: 0.03956045
p_int: 0.999999106
p_ni: 8.94e-7
Score: 0.641
Data Source: BioPlex,STRINGDB
FAM53C
Tdark
Novelty: 1.18764113
p_int: 0.999998253
p_ni: 0.000001747
Score: 0.719
Data Source: BioPlex,STRINGDB
FBRS
Tbio
Novelty: 0.13646817
p_int: 0.999998101
p_ni: 0.000001899
Score: 0.613
Data Source: BioPlex,STRINGDB
AUTS2
Tbio
Novelty: 0.01782909
p_int: 0.999996179
p_ni: 4.28e-7
p_wrong: 0.000003393
Score: 0.689
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  41.35

PubMed score by year
PubTator Score  383.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer