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Tbio
UFM1
Ubiquitin-fold modifier 1

Protein Summary
Description
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (PubMed:15071506, PubMed:20018847). TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable). UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 60317 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239878
  • ENSP00000239878
  • ENSG00000120686
  • ENST00000379649
  • ENSP00000368970

Symbol
  • C13orf20
  • HLD14
  • BM-002
  • C13orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.76
virus perturbation
0.76
tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.13   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.13   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Protein-Protein Interactions (93)
1 – 10 of 93
UBA5
Tbio
Novelty: 0.05089296
p_int: 0.987091259
p_ni: 0.012908741
Score: 0.997
Data Source: BioPlex,STRINGDB
S100A6
Tbio
Novelty: 0.00176164
p_int: 0.951969669
p_ni: 0.048030307
p_wrong: 2.4e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
UFC1
Tbio
Novelty: 0.04181639
Score: 0.993
Data Source: STRINGDB
UFSP2
Tbio
Family: Enzyme
Novelty: 0.12630722
Score: 0.988
Data Source: STRINGDB
UFSP1
Tdark
Family: Enzyme
Novelty: 0.22843575
Score: 0.987
Data Source: STRINGDB
UFL1
Tbio
Family: Enzyme
Novelty: 0.02941148
Score: 0.948
Data Source: STRINGDB
DDRGK1
Tbio
Novelty: 0.10774064
Score: 0.904
Data Source: STRINGDB
URM1
Tbio
Novelty: 0.02579093
Score: 0.896
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.885
Data Source: STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.863
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.13

PubMed score by year
PubTator Score  26.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer